Self-Assembled Lipid Prodrug Nanomedicines for Cancerous and Noncancerous Diseases

Dear Colleagues,

In recent years, there has been a growing trend in utilizing lipid-prodrug-based nanoassemblies (LPNs) for drug delivery, which have gained popularity due to their numerous advantages. A typical lipid prodrug encompasses a lipid carrier material, native drug, and a chemical spacer that possesses the potential to respond to stimuli. Through hydrophilic and hydrophobic interactions, lipid prodrugs spontaneously form supramolecular structures when introduced to aqueous environments. LPNs offer a combination of benefits derived from prodrugs and nanoparticles, facilitating drug release in response to stimuli while improving drug stability, bioavailability, and intracellular delivery.

The objective of this Special Issue of Pharmaceutics is to compile original research and review papers that focus on the development of lipid-prodrug-based nano-drug delivery systems for effectively treating severe diseases such as cancer, neurological disorders, infectious diseases, and uncontrolled inflammation.

Dr. Xiao Dong
Guest Editor

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• lipid prodrug
• self-assembly
• nanomedicine
• drug delivery
• stimuli responsive
• drug release
• cancer
• non-cancerous disease