New Pharmaceutical Targets to Counteract Chronic Inflammation

Dear Colleagues,

Inflammation is a protective response of organisms to harmful stimuli including pathogens, damaged cells, and toxic compounds. While finely regulated in a healthy organism, uncontrolled inflammation may become chronic, contributing to the onset of a large number of pathological conditions, spanning from cancer to autoimmune disorders, from diabetes-related complications to infections, from kidney to ocular diseases, and to a variety of age-related degenerative conditions. For many of these pathologies, therapeutic intervention is frequently absent or inadequate. Over the last years, molecular understanding of the mechanisms and signalling pathways leading to chronic inflammation has enabled the identification of new, general and effective pharmaceutic targets (proteolytic enzymes, Toll-like receptors, inflammatory factors, growth factors, and inflammatory metabolites) to be exploited for innovative treatments of inflammatory diseases.

The goal of this Special Issue is to highlight and collate scientific publications and reviews on interesting pharmaceutical studies (regarding the identification of new pharmaceutical targets, innovative pharmaceutic treatments and formulations, and insights into the mechanisms of therapeutic drugs in chronic inflammatory diseases) that aim to tackle and cure diseases characterized by chronic inflammation.

Dr. Maria De Fenza
Prof. Vincenzo Pavone
Dr. Daniele D'Alonzo
Dr. Giuseppe Castellano
Guest Editors

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• dysregulated chemotaxis
• chronic inflammation
• ocular diseases
• focal segmental glomerulosclerosis
• acute kidney disease
• new pharmaceutical targets
• innovative pharmaceutic treatments and formulations