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Bionanotechnology and Biomaterials in Medicine
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Bionanotechnology and Biomaterials in Medicine

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biomedical Sensors".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 9045

Special Issue Editors

Dr. Azhar Ilyas

E-Mail Website
Guest Editor
Department of Electrical and Computer Engineering, College of Engineering & Computing Sciences, New York Institute of Technology (NYIT), Northern Boulevard, Old Westbury, NY 11568, USA
Interests: biomedical devices; nanotechnology; disease diagnostics; biomaterials; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Wan Yuan

E-Mail Website
Guest Editor
Biomedical Engineering Department, Binghamton University, Vestal, NY 13850, USA
Interests: Point of Care Diagnostics; Biomimetic Micro/nano-technologies; Targeted Drug Delivery; Cancer Liquid Biopsy; Nanomedicine

Special Issue Information

Dear Colleagues,

The fields of nano- and biotechnology have seen unparalleled growth and development in the last two decades. Through its evolution, nanotechnology holds some of the greatest promise, drawing up contributions from medicine, engineering, chemistry, physics, biology, and materials science. Innovations in technology and materials at the micro- and nanoscale offer tremendous opportunities for solving important problems in health sciences and medicine and enable a broad range of applications in diagnostics, sensing, therapeutics, and tissue engineering. These technologies will have a significant impact on medicine and biology in the areas of single cell detection, diagnosis and combating disease, providing specificity of drug delivery for therapy, avoiding time-consuming steps to provide faster results, understanding the role of surface chemistry in cellular attachment, surface bioactivity, and gene expressions for enhanced cellular functions and rapid tissue healing.

This Special Issue aims to showcase advancements in nanoscience and biomaterials, covering a broad range of applications in the field of sensing and characterization of biological entities (cells, bacteria, viruses, proteins, DNA) and examining therapeutics (cell–surface interactions, gene expressions). We wish to cover research work that focuses on developing biosensors, microfluidic devices, nanoelectronics, structural biomaterials, tissue engineering, and other technology innovations employed in medicine.

Dr. Azhar Ilyas
Dr. Wan Yuan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biosensors
  • Biomedical circuits and systems
  • Bioelectronics
  • Microfluidic devices
  • Biomaterials
  • Tissue engineering
  • Bone regeneration

Published Papers (3 papers)

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Research

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14 pages, 1677 KiB  
Article
Development of a Point-of-Care Assay for HIV-1 Viral Load Using Higher Refractive Index Antibody-Coated Microbeads
by Mazhar Sher, Benjamin Coleman, Massimo Caputi and Waseem Asghar
Sensors 2021, 21(5), 1819; https://0-doi-org.brum.beds.ac.uk/10.3390/s21051819 - 05 Mar 2021
Cited by 6 | Viewed by 2456
Abstract
The detection of viruses using imaging techniques is challenging because of the weak scattering of light generated by the targets of sizes in the nanometer range. The system we have developed overcomes the light scattering problems by utilizing antibody-coated microbeads of higher index [...] Read more.
The detection of viruses using imaging techniques is challenging because of the weak scattering of light generated by the targets of sizes in the nanometer range. The system we have developed overcomes the light scattering problems by utilizing antibody-coated microbeads of higher index of refraction that can specifically bind with viruses and increase the acceptance angle. Using the new technology, we have developed a portable, cost-effective, and field-deployable platform for the rapid quantification of HIV-1 viral load for point-of-care (POC) settings. The system combines microfluidics with a wide field of view lensless imaging technology. Highly specific antibodies are functionalized to a glass slide inside a microchip to capture HIV-1 virions. The captured virions are then bound by antibody-conjugated microbeads, which have a higher refraction index. The microbeads—HIV-1 virions complexes generate diffraction patterns that are detected with a custom-built imaging setup and rapidly and accurately quantified by computational analysis. This platform technology enables fast nanoscale virus imaging and quantification from biological samples and thus can play a significant role in the detection and management of viral diseases. Full article
(This article belongs to the Special Issue Bionanotechnology and Biomaterials in Medicine)
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13 pages, 1471 KiB  
Article
Visualization Method for the Cell-Level Vesicle Transport Using Optical Flow and a Diverging Colormap
by Seohyun Lee, Hyuno Kim, Hideo Higuchi and Masatoshi Ishikawa
Sensors 2021, 21(2), 522; https://0-doi-org.brum.beds.ac.uk/10.3390/s21020522 - 13 Jan 2021
Cited by 6 | Viewed by 2545
Abstract
Elucidation of cell-level transport mediated by vesicles within a living cell provides key information regarding viral infection processes and also drug delivery mechanisms. Although the single-particle tracking method has enabled clear analysis of individual vesicle trajectories, information regarding the entire cell-level intracellular transport [...] Read more.
Elucidation of cell-level transport mediated by vesicles within a living cell provides key information regarding viral infection processes and also drug delivery mechanisms. Although the single-particle tracking method has enabled clear analysis of individual vesicle trajectories, information regarding the entire cell-level intracellular transport is hardly obtainable, due to the difficulty in collecting a large dataset with current methods. In this paper, we propose a visualization method of vesicle transport using optical flow, based on geometric cell center estimation and vector analysis, for measuring the trafficking directions. As a quantitative visualization method for determining the intracellular transport status, the proposed method is expected to be universally exploited in various biomedical cell image analyses. Full article
(This article belongs to the Special Issue Bionanotechnology and Biomaterials in Medicine)
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Review

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20 pages, 1072 KiB  
Review
Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering
by Shebin Tharakan, Shams Khondkar and Azhar Ilyas
Sensors 2021, 21(22), 7477; https://0-doi-org.brum.beds.ac.uk/10.3390/s21227477 - 10 Nov 2021
Cited by 17 | Viewed by 3139
Abstract
Bioprinting stem cells into three-dimensional (3D) scaffolds has emerged as a new avenue for regenerative medicine, bone tissue engineering, and biosensor manufacturing in recent years. Mesenchymal stem cells, such as adipose-derived and bone-marrow-derived stem cells, are capable of multipotent differentiation in a 3D [...] Read more.
Bioprinting stem cells into three-dimensional (3D) scaffolds has emerged as a new avenue for regenerative medicine, bone tissue engineering, and biosensor manufacturing in recent years. Mesenchymal stem cells, such as adipose-derived and bone-marrow-derived stem cells, are capable of multipotent differentiation in a 3D culture. The use of different printing methods results in varying effects on the bioprinted stem cells with the appearance of no general adverse effects. Specifically, extrusion, inkjet, and laser-assisted bioprinting are three methods that impact stem cell viability, proliferation, and differentiation potential. Each printing method confers advantages and disadvantages that directly influence cellular behavior. Additionally, the acquisition of 3D bioprinters has become more prominent with innovative technology and affordability. With accessible technology, custom 3D bioprinters with capabilities to print high-performance bioinks are used for biosensor fabrication. Such 3D printed biosensors are used to control conductivity and electrical transmission in physiological environments. Once printed, the scaffolds containing the aforementioned stem cells have a significant impact on cellular behavior and differentiation. Natural polymer hydrogels and natural composites can impact osteogenic differentiation with some inducing chondrogenesis. Further studies have shown enhanced osteogenesis using cell-laden scaffolds in vivo. Furthermore, selective use of biomaterials can directly influence cell fate and the quantity of osteogenesis. This review evaluates the impact of extrusion, inkjet, and laser-assisted bioprinting on adipose-derived and bone-marrow-derived stem cells along with the effect of incorporating these stem cells into natural and composite biomaterials. Full article
(This article belongs to the Special Issue Bionanotechnology and Biomaterials in Medicine)
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