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Nanostructured Materials for Optical Biosensing: Progress and Perspectives

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 3209

Special Issue Editor


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Guest Editor
Department of Basic and Applied Science for Engineering, University of Rome La Sapienza, Via A. Scarpa 16, 00161 Rome, Italy
Interests: optical biosensors; smart materials for sensing; surface chemistry

Special Issue Information

Dear Colleagues,

Nanostructured materials represent a vibrant area of research and a techno-economic sector with full expansion in many application domains. In particular, in the field of optical biosensors, nanostructured materials have gained prominence in technological advancements due to their tunable physical characteristics in manipulating light-biological matter interaction resulting in enhanced performance with respect to their bulk counterparts. The final goal of this Special Issue is to provide novel and smart optical biosensing approaches based on nanostructured materials. The Special Issue will focus on two biological topics: cancer related biomarkers and virus detection. Cancer biomarkers are a wide range of biochemical entities, such as nucleic acids, proteins, sugars, small metabolites, and cytokinetic parameters, as well as entire tumour cells found in body fluids. They are routinely used in clinical environment for diagnosis, prognosis, and the prediction of treatment efficacy and recurrence. The importance of virus and viral proteins detection is dramatically demonstrated by our recent experiences. In particular, the health emergency related to SARS-CoV-2 put in evidence our inadequate response in terms of smart biosensing solutions for mass screening.

This Special Issue of Sensors welcomes both reviews and original research articles on the field of new nanostructured materials for optical biosensing. Topics include, but are not restricted to, plasmonic configurations, photonic crystals-based biosensors, metamaterials and metasurfaces for optical biosensing, label-free and/or fluorescence optical platforms, such as lab-on-a-chip and optical fiber sensing based on nanostructures. Smart bioreceptor immobilization procedures and their integration into nanostructured optical sensors are also of interest.

Dr. Alberto Sinibaldi
Guest Editor

Manuscript Submission Information

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Keywords

  • Photonic Crystals
  • Metamaterials and Metasurfaces
  • Plasmonics
  • Nanoparticles
  • Label-free/Fluorescence biosensing systems
  • Lab-on-Chips
  • Nanostructured Fiber Optics-based biosensors
  • Smart bioreceptor conjugation
  • Cancer Biomarker Detection
  • Virus Detection

Published Papers (1 paper)

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Research

27 pages, 7900 KiB  
Article
Resonant Subwavelength and Nano-Scale Grating Structures for Biosensing Application: A Comparative Study
by Mohammad Abutoama, Marwan Abuleil and Ibrahim Abdulhalim
Sensors 2021, 21(13), 4523; https://0-doi-org.brum.beds.ac.uk/10.3390/s21134523 - 01 Jul 2021
Cited by 7 | Viewed by 2557
Abstract
Resonant-based sensors are attractive optical structures due to the easy detection of shifts in the resonance location in response to variations in the analyte refractive index (RI) in comparison to non-resonant-based sensors. In particular, due to the rapid progress of nanostructures fabrication methods, [...] Read more.
Resonant-based sensors are attractive optical structures due to the easy detection of shifts in the resonance location in response to variations in the analyte refractive index (RI) in comparison to non-resonant-based sensors. In particular, due to the rapid progress of nanostructures fabrication methods, the manufacturing of subwavelength and nano-scale gratings in a large area and at a low cost has become possible. A comparative study is presented involving analysis and experimental work on several subwavelength and nanograting structures, highlighting their nano-scale features’ high potential in biosensing applications, namely: (i) Thin dielectric grating on top of thin metal film (TDGTMF), which can support the excitation of extended surface plasmons (ESPs), guided mode resonance, or leaky mode; (ii) reflecting grating for conventional ESP resonance (ESPR) and cavity modes (CMs) excitation; (iii) thick dielectric resonant subwavelength grating exhibiting guided mode resonance (GMR) without a waveguide layer. Among the unique features, we highlight the following: (a) Self-referenced operation obtained using the TDGTMF geometry; (b) multimodal operation, including ESPR, CMs, and surface-enhanced spectroscopy using reflecting nanograting; (c) phase detection as a more sensitive approach in all cases, except the case of reflecting grating where phase detection is less sensitive than intensity or wavelength detection. Additionally, intensity and phase detection modes were experimentally demonstrated using off-the-shelf grating-based optical compact discs as a low-cost sensors available for use in a large area. Several flexible designs are proposed for sensing in the visible and infrared spectral ranges based on the mentioned geometries. In addition, enhanced penetration depth is also proposed for sensing large entities such as cells and bacteria using the TDGTMF geometry. Full article
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