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Recent Advances in Biophotonics Sensors
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Recent Advances in Biophotonics Sensors

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 6492

Special Issue Editor

Prof. Dr. Stephen Holler

E-Mail Website
Guest Editor
Department of Physics & Engineering Physics, Fordham University, Freeman Hall B06A, 441 E. Fordham Road, Bronx, NY 10458, USA
Interests: biological sensor development; environmental sensing; micro-optical sensors; whispering gallery mode biosensors; microcavity photonics; light scattering from bio-aerosols; fluorescence and absorption spectroscopy; cavity ringdown spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The emergence of SARS-CoV2 in late 2019 and the ensuing pandemic underscore the need for rapid and robust sensor platforms for the detection of biological matter such as bacteria and viruses. Biphotonic sensors are the class of optical sensors that satisfy the criteria for both speed and robustness in the face of current challenges. We are soliciting manuscripts for a Special Issue of Sensors that will focus on both theoretical and experimental advances in biophotonic sensors. The variety of approaches can include but are not limited to platforms that utilize fluorescence, Raman, absorption spectroscopy, or other photonic sensing techniques. Such sensor platforms are ideal for trace detection of a host of biological analytes, such as DNA, protein, bacteria, and virus. We welcome contributions of original research or comprehensive reviews that illustrate the diversity and importance of this exciting area of research.

Prof. Dr. Stephen Holler
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • integrated optics, interference, waveguide, interferometer
  • microcavity, whispering gallery mode, ring resonator
  • biological agent
  • bacteria, virus, protein, DNA, RNA
  • raman, fluorescence, absorption spectroscopy, interferometry

Published Papers (3 papers)

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Research

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18 pages, 5728 KiB  
Article
Simultaneous Two- and Three-Photon Deep Imaging of Autofluorescence in Bacterial Communities
by Alma Fernández, Anton Classen, Nityakalyani Josyula, James T. Florence, Alexei V. Sokolov, Marlan O. Scully, Paul Straight and Aart J. Verhoef
Sensors 2024, 24(2), 667; https://0-doi-org.brum.beds.ac.uk/10.3390/s24020667 - 20 Jan 2024
Viewed by 886
Abstract
The intrinsic fluorescence of bacterial samples has a proven potential for label-free bacterial characterization, monitoring bacterial metabolic functions, and as a mechanism for tracking the transport of relevant components through vesicles. The reduced scattering and axial confinement of the excitation offered by multiphoton [...] Read more.
The intrinsic fluorescence of bacterial samples has a proven potential for label-free bacterial characterization, monitoring bacterial metabolic functions, and as a mechanism for tracking the transport of relevant components through vesicles. The reduced scattering and axial confinement of the excitation offered by multiphoton imaging can be used to overcome some of the limitations of single-photon excitation (e.g., scattering and out-of-plane photobleaching) to the imaging of bacterial communities. In this work, we demonstrate in vivo multi-photon microscopy imaging of Streptomyces bacterial communities, based on the excitation of blue endogenous fluorophores, using an ultrafast Yb-fiber laser amplifier. Its parameters, such as the pulse energy, duration, wavelength, and repetition rate, enable in vivo multicolor imaging with a single source through the simultaneous two- and three-photon excitation of different fluorophores. Three-photon excitation at 1040 nm allows fluorophores with blue and green emission spectra to be addressed (and their corresponding ultraviolet and blue single-photon excitation wavelengths, respectively), and two-photon excitation at the same wavelength allows fluorophores with yellow, orange, or red emission spectra to be addressed (and their corresponding green, yellow, and orange single-photon excitation wavelengths). We demonstrate that three-photon excitation allows imaging over a depth range of more than 6 effective attenuation lengths to take place, corresponding to an 800 micrometer depth of imaging, in samples with a high density of fluorescent structures. Full article
(This article belongs to the Special Issue Recent Advances in Biophotonics Sensors)
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25 pages, 3186 KiB  
Article
Surface Conditioning Effects on Submerged Optical Sensors: A Comparative Study of Fused Silica, Titanium Dioxide, Aluminum Oxide, and Parylene C
by Zibin Nan, Pascal Floquet, Didier Combes, Claire Tendero and Mickaël Castelain
Sensors 2023, 23(23), 9546; https://0-doi-org.brum.beds.ac.uk/10.3390/s23239546 - 30 Nov 2023
Viewed by 642
Abstract
Optical sensors excel in performance but face efficacy challenges when submerged due to potential surface colonization, leading to signal deviation. This necessitates robust solutions for sustained accuracy. Protein and microorganism adsorption on solid surfaces is crucial in antibiofilm studies, contributing to conditioning film [...] Read more.
Optical sensors excel in performance but face efficacy challenges when submerged due to potential surface colonization, leading to signal deviation. This necessitates robust solutions for sustained accuracy. Protein and microorganism adsorption on solid surfaces is crucial in antibiofilm studies, contributing to conditioning film and biofilm formation. Most studies focus on surface characteristics (hydrophilicity, roughness, charge, and composition) individually for their adhesion impact. In this work, we tested four materials: silica, titanium dioxide, aluminum oxide, and parylene C. Bovine Serum Albumin (BSA) served as the biofouling conditioning model, assessed with X-ray photoelectron spectroscopy (XPS). Its effect on microorganism adhesion (modeled with functionalized microbeads) was quantified using a shear stress flow chamber. Surface features and adhesion properties were correlated via Principal Component Analysis (PCA). Protein adsorption is influenced by nanoscale roughness, hydrophilicity, and likely correlated with superficial electron distribution and bond nature. Conditioning films alter the surface interaction with microbeads, affecting hydrophilicity and local charge distribution. Silica shows a significant increase in microbead adhesion, while parylene C exhibits a moderate increase, and titanium dioxide shows reduced adhesion. Alumina demonstrates notable stability, with the conditioning film minimally impacting adhesion, which remains low. Full article
(This article belongs to the Special Issue Recent Advances in Biophotonics Sensors)
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Review

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28 pages, 6884 KiB  
Review
Microscopies Enabled by Photonic Metamaterials
by Yanyu Xiong, Nantao Li, Congnyu Che, Weijing Wang, Priyash Barya, Weinan Liu, Leyang Liu, Xiaojing Wang, Shaoxiong Wu, Huan Hu and Brian T. Cunningham
Sensors 2022, 22(3), 1086; https://0-doi-org.brum.beds.ac.uk/10.3390/s22031086 - 30 Jan 2022
Cited by 15 | Viewed by 4275
Abstract
In recent years, the biosensor research community has made rapid progress in the development of nanostructured materials capable of amplifying the interaction between light and biological matter. A common objective is to concentrate the electromagnetic energy associated with light into nanometer-scale volumes that, [...] Read more.
In recent years, the biosensor research community has made rapid progress in the development of nanostructured materials capable of amplifying the interaction between light and biological matter. A common objective is to concentrate the electromagnetic energy associated with light into nanometer-scale volumes that, in many cases, can extend below the conventional Abbé diffraction limit. Dating back to the first application of surface plasmon resonance (SPR) for label-free detection of biomolecular interactions, resonant optical structures, including waveguides, ring resonators, and photonic crystals, have proven to be effective conduits for a wide range of optical enhancement effects that include enhanced excitation of photon emitters (such as quantum dots, organic dyes, and fluorescent proteins), enhanced extraction from photon emitters, enhanced optical absorption, and enhanced optical scattering (such as from Raman-scatterers and nanoparticles). The application of photonic metamaterials as a means for enhancing contrast in microscopy is a recent technological development. Through their ability to generate surface-localized and resonantly enhanced electromagnetic fields, photonic metamaterials are an effective surface for magnifying absorption, photon emission, and scattering associated with biological materials while an imaging system records spatial and temporal patterns. By replacing the conventional glass microscope slide with a photonic metamaterial, new forms of contrast and enhanced signal-to-noise are obtained for applications that include cancer diagnostics, infectious disease diagnostics, cell membrane imaging, biomolecular interaction analysis, and drug discovery. This paper will review the current state of the art in which photonic metamaterial surfaces are utilized in the context of microscopy. Full article
(This article belongs to the Special Issue Recent Advances in Biophotonics Sensors)
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