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Electrochemical Biosensors for Cell-Secreted and Cell-Surface-Expressed Biomarkers Detection
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Electrochemical Biosensors for Cell-Secreted and Cell-Surface-Expressed Biomarkers Detection

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (1 May 2022) | Viewed by 2866

Special Issue Editors

Dr. Tugba Kilic

E-Mail Website
Guest Editor
Swiss National Science Foundation Postdoctoral Research Fellow, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Interests: in vitro diagnostics; organs on chips; electrochemical biosensors
Dr. Hsing-Ying Lin

E-Mail Website
Guest Editor
Institute of Biomedical Engineering, National Tsing Hua university, Hsinchu, Taiwan
Interests: point-of-care devices and analytical methods in healthcare; translational medicine applications; nanophotonics and plasmonics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite all the advances in medicine, currently, the point of diagnosis determines, most of the time, the success of a medical treatment and the overall survival rate of a disease. Available diagnostic approaches often fail due to insufficient sensitivity of the method or the selectivity of the biomarker. For the past decade, studies showed the diagnostic and prognostic value of cell-secreted biomarkers and cell-surface-expressed proteins. Cancer, immunological and hematological diseases are only a few examples where body fluids can be used to perform cell secretome profiling not only for early diagnosis purposes but also for personalized/advanced therapies. In vitro noninvasive diagnostic approaches, such as (bio)sensors and immunosensors developed for detection of these biomarkers, have gained great attention in clinics.

It is our pleasure to welcome your contribution to this Special Issue where we aim to publish state-of-the art research results of biosensors used for in vitro or in vivo biomarker detection. Original papers describing completed and unpublished work that are not currently under review by any other journal, magazine or conference, are solicited.

Dr. Tugba Kilic
Dr. Hsing-Ying Lin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell-secreted-biomarker detection
  • secretome analysis
  • immunosensors
  • in vitro diagnostics

Published Papers (1 paper)

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Research

13 pages, 2475 KiB  
Article
In Vitro Electrochemical Detection of Hydrogen Peroxide in Activated Macrophages via a Platinum Microelectrode Array
by Victor M. Carriere, Jolin P. Rodrigues, Chao Tan, Prabhu Arumugam and Scott Poh
Sensors 2021, 21(16), 5607; https://0-doi-org.brum.beds.ac.uk/10.3390/s21165607 - 20 Aug 2021
Cited by 7 | Viewed by 2477
Abstract
Oxidative stress, an excess of endogenous or exogenous reactive oxygen species (ROS) in the human body, is closely aligned with inflammatory responses. ROS such as hydrogen peroxide (H2O2), superoxide, and radical hydroxyl ions serve essential functions in fighting infection; [...] Read more.
Oxidative stress, an excess of endogenous or exogenous reactive oxygen species (ROS) in the human body, is closely aligned with inflammatory responses. ROS such as hydrogen peroxide (H2O2), superoxide, and radical hydroxyl ions serve essential functions in fighting infection; however, chronic elevation of these species irreversibly damages cellular components. Given the central role of inflammation in a variety of diseases, including Alzheimer’s disease and rheumatoid arthritis, a low-cost, extracellular, non-invasive assay of H2O2 measurement is needed. This work reports the use of a platinum microelectrode array (Pt MEA)-based ceramic probe to detect time- and concentration-dependent variations in H2O2 production by activated RAW 264.7 macrophages. First, these cells were activated by lipopolysaccharide (LPS) to induce oxidative stress. Chronoamperometry was then employed to detect the quantity of H2O2 released by cells at various time intervals up to 48 h. The most stimulatory concentration of LPS was identified. Further experiments assessed the anti-inflammatory effect of dexamethasone (Dex), a commonly prescribed steroid medication. As expected, the probe detected significantly increased H2O2 production by LPS-doped macrophages, subsequently diminishing the pro-inflammatory effect in LPS-doped cells treated with Dex. These results strongly support the use of this probe as a non-invasive, robust, point-of-care test of inflammation, with a high potential for multiplexing in further studies. Full article
(This article belongs to the Special Issue Electrochemical Biosensors for Cell-Secreted and Cell-Surface-Expressed Biomarkers Detection)
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