Special Issue "Potency, Duration of Action, and Pharmacodynamics of Human Neurotoxins"
Deadline for manuscript submissions: closed (15 December 2020).
Interests: botulinum neurotoxins; stem cell derived neuronal cultures; cell assays; neurotoxins
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: Advances in Clostridial and Related Neurotoxins
Natural and synthetic neurotoxins utilize numerous mechanisms to intoxicate and persist in their hosts. For example, botulinum neurotoxins (BoNTs) are the most potent protein toxins for humans. BoNTs are produced by the anaerobic spore forming clostridia, primarily C. botulinum. Botulism is characterized by long-lasting flaccid paralysis due to the continuous block of neurotransmitter release at neuromuscular junctions. Genome sequencing has shown that BoNTs comprise a large and diverse protein family, with at least seven distinguishable serotypes and numerous subtypes within these serotypes. While the overall basis for entry into neurons and mechansim of cleavage and recogniton SNARE proteins are similar, individual BoNT serotypes and subtypes differ in potency, onset of symptoms, duration of action, pharmacodynamic behavior, and species specificity. Little is known about the mechanisms underlying the specificity of these biological characteristics. Research into these mechanisms will provide insights in the expansion of BoNT pharmaceutical potential and development of countermeasures and treatment modalities against botulism. This series welcomes primary articles and reviews that address the basis for the biological spectrum of the action of BoNTs and other neurotoxins on neurons, humans, and model systems, utilizing informatics, computational biology, and laboratory-based approaches.
Dr. Sabine Pellett
Prof. Joseph Barbieri
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- botulinum neurotoxin