Pathogenesis of Pregnancy-Related Complications 2.0

Topic Information

Dear Colleagues,

Preeclampsia, HELLP syndrome, fetal growth restriction, gestational diabetes mellitus, preterm birth (preterm prelabor rupture of membranes and spontaneous preterm labor), and an invasive placenta are major complications responsible for maternal and perinatal morbidity and mortality. The elucidation of the pathogenetic mechanisms related to the initiation and onset of severe pregnancy-related complications enables the identification of potential biomarkers for the early stratification of at-risk patients. Additionally, pregnancy-related complications induce long-term metabolic and vascular abnormalities that might increase the overall risk of metabolic, cardiovascular, cerebrovascular, kidney, and other diseases later in life in mothers and their offspring. This Topic aims to provide an overview of the latest research on the mechanisms associated with pregnancy-related complications as well as on the contributions of pregnancy-related complications to the later development of various diseases. This will include the underlying mechanisms, diagnostics/prognostics, and treatment strategies associated with pregnancy-related complications, and will be of interest to scientists and clinicians working in this quickly expanding area.

Topics will include (but are not limited to) the following:

• Pathogenesis of pregnancy-related complications;
• Diagnosis and prognosis of pregnancy-related complications;
• Short-term and long-term follow-up after pregnancy-related complications (mothers and offspring);
• Novel treatment modalities of pregnancy-related complications and their short-term as well as long-term consequences.

Prof. Dr. Ilona Hromadnikova
Dr. Katerina Kotlabova
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Biomedicines biomedicines	4.7	3.7	2013	15.4 Days	CHF 2600	Submit
Current Issues in Molecular Biology cimb	3.1	2.4	1999	13.5 Days	CHF 2200	Submit
Endocrines endocrines	-	-	2020	27.2 Days	CHF 1000	Submit
International Journal of Molecular Sciences ijms	5.6	7.8	2000	16.3 Days	CHF 2900	Submit
Journal of Molecular Pathology jmp	-	-	2020	24.9 Days	CHF 1000	Submit
Life life	3.2	2.7	2011	17.5 Days	CHF 2600	Submit
Reproductive Medicine reprodmed	-	-	2020	29.2 Days	CHF 1000	Submit

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Published Papers (3 papers)

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All Biomedicines CIMB Endocrines IJMS JMP Life Reprod. Med.

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12 pages, 470 KiB  

Open AccessReview

Maternal Influenza and Offspring Neurodevelopment

by Marya Egorova, Vladimir Egorov and Yana Zabrodskaya

Curr. Issues Mol. Biol. 2024, 46(1), 355-366; https://0-doi-org.brum.beds.ac.uk/10.3390/cimb46010023 - 02 Jan 2024

Viewed by 1123

Abstract

This review examines the complex interactions between maternal influenza infection, the immune system, and the neurodevelopment of the offspring. It highlights the importance of high-quality studies to clarify the association between maternal exposure to the virus and neuropsychiatric disorders in the offspring. Additionally, [...] Read more.

This review examines the complex interactions between maternal influenza infection, the immune system, and the neurodevelopment of the offspring. It highlights the importance of high-quality studies to clarify the association between maternal exposure to the virus and neuropsychiatric disorders in the offspring. Additionally, it emphasizes that the development of accurate animal models is vital for studying the impact of infectious diseases during pregnancy and identifying potential therapeutic targets. By drawing attention to the complex nature of these interactions, this review underscores the need for ongoing research to improve the understanding and outcomes for pregnant women and their offspring. Full article

(This article belongs to the Topic Pathogenesis of Pregnancy-Related Complications 2.0)

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17 pages, 1523 KiB  

Open AccessReview

Regulation of SIRT1 in Ovarian Function: PCOS Treatment

by Xinrong Li, Yuxu He, Shuang Wu, Peiwen Zhang, Mailin Gan, Lei Chen, Ye Zhao, Lili Niu, Shunhua Zhang, Yanzhi Jiang, Zongyi Guo, Jinyong Wang, Linyuan Shen and Li Zhu

Curr. Issues Mol. Biol. 2023, 45(3), 2073-2089; https://0-doi-org.brum.beds.ac.uk/10.3390/cimb45030133 - 02 Mar 2023

Cited by 4 | Viewed by 2278

Abstract

The sirtuin family, a group of NAD+-dependent class 3 histone deacetylases (HDACs), was extensively studied initially as a group of longevity genes that are activated in caloric restriction and act in concert with nicotinamide adenine dinucleotides to extend the lifespan. Subsequent studies have [...] Read more.

The sirtuin family, a group of NAD+-dependent class 3 histone deacetylases (HDACs), was extensively studied initially as a group of longevity genes that are activated in caloric restriction and act in concert with nicotinamide adenine dinucleotides to extend the lifespan. Subsequent studies have found that sirtuins are involved in various physiological processes, including cell proliferation, apoptosis, cell cycle progression, and insulin signaling, and they have been extensively studied as cancer genes. In recent years, it has been found that caloric restriction increases ovarian reserves, suggesting that sirtuins may play a regulatory role in reproductive capacity, and interest in the sirtuin family has continued to increase. The purpose of this paper is to summarize the existing studies and analyze the role and mechanism of SIRT1, a member of the sirtuin family, in regulating ovarian function. Research and review on the positive regulation of SIRT1 in ovarian function and its therapeutic effect on PCOS syndrome. Full article

(This article belongs to the Topic Pathogenesis of Pregnancy-Related Complications 2.0)

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15 pages, 566 KiB  

Open AccessReview

Difficulties in Adaptation of the Mother and Newborn via Cesarean Section versus Natural Birth—A Narrative Review

by Vasile Valeriu Lupu, Ingrith Crenguta Miron, Anca Adam Raileanu, Iuliana Magdalena Starcea, Ancuta Lupu, Elena Tarca, Adriana Mocanu, Ana Maria Laura Buga, Valeriu Lupu and Silvia Fotea

Life 2023, 13(2), 300; https://0-doi-org.brum.beds.ac.uk/10.3390/life13020300 - 21 Jan 2023

Cited by 19 | Viewed by 4262

Abstract

Birth is a physiological act that is part of the morpho-functional economy of the maternal body. Each stage in the act of birth has a predetermined pathway that is neurohormonally induced and morpho-functionally established through specific and characteristic adaptations. Like maternity, childbirth also [...] Read more.

Birth is a physiological act that is part of the morpho-functional economy of the maternal body. Each stage in the act of birth has a predetermined pathway that is neurohormonally induced and morpho-functionally established through specific and characteristic adaptations. Like maternity, childbirth also has an important impact on the maternal body as a biological structure and psycho-emotional behavior. Cesarean section performed at the request of the mother with no medical underlying conditions besides the prolonged hospitalization risk can also cause breathing problems in children, delayed breastfeeding, and possible complications in a future pregnancy. Vaginal birth remains the path of choice for a physiological evolution pregnancy. Although erroneously considered safe and easy today, cesarean section delivery must remain an emergency procedure or a procedure recommended for pregnancies where birth is a risk to the mother and to the child, as cesarean section itself is a risk factor for negative outcomes for both mother and baby. This review summarizes the impact that both cesarean section and natural birth have on mother and newborn in their attempt to adapt to postpartum events and extrauterine life. Full article

(This article belongs to the Topic Pathogenesis of Pregnancy-Related Complications 2.0)

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