A Cumulative Muscle Index and Its Parameters for Predicting Future Cognitive Decline: Longitudinal Outcomes of the ASPRA Cohort
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Assessment of Cognitive Performance
2.3. Assessment of Sarcopenia
2.4. Assessment of Other Geriatric Parameters
2.5. Statistical Analysis
3. Results
3.1. Baseline Characteristics
3.2. Sarcopenia Status and Cognitive Decline
3.3. Sarcopenia Parameters and Cognitive Decline
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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No Decline of MMSE | Meaningful Decline of MMSE | p | |
---|---|---|---|
Number | 407 (49.2%) | 420 (50.8%) | |
Age | 73.1(5.4) | 73.9(5.5) | 0.025 |
Sex (male) | 169 (41.5%) | 169 (40.2%) | 0.707 |
Education level (years) | 5.0 (3.2) | 5.0 (3.2) | 0.948 |
Multimorbidity | 158 (38.8%) | 165 (39.3%) | 0.891 |
Hypertension | 218 (53.6%) | 232 (55.2%) | 0.629 |
Diabetes | 69 (17.0%) | 71 (16.9%) | 0.985 |
Stroke | 12 (3.0%) | 9 (2.0%) | 0.462 |
Body mass index (kg/m²) | 24.8 (3.5) | 24.7 (3.4) | 0.776 |
Muscle mass index (kg/m²) | 6.5 (1.2) | 6.4 (1.2) | 0.486 |
Gait speed (m/s) | 0.81 (0.30) | 0.78 (0.28) | 0.112 |
Grip strength (kg) | 23.2 (9.5) | 22.1 (9.7) | 0.099 |
ADL impairment | 43 (10.6%) | 43 (10.2%) | 0.878 |
IADL impairment | 101 (24.8%) | 148 (35.2%) | 0.001 |
Polypharmacy | 79 (19.4%) | 104 (24.8%) | 0.064 |
Risk of malnutrition | 78 (19.2%) | 86 (20.5%) | 0.636 |
Depressive mood | 28 (6.9%) | 34 (8.1%) | 0.507 |
MMSE score | 25.0 (3.7) | 26.3 (3.6) | <0.001 |
Linear Regression Model 1 | Linear Regression Model 2 | |||
---|---|---|---|---|
Coefficients (SE) | p | Coefficients (SE) | p | |
Original AWGS | −0.36 (0.22) | 0.107 | −0.31 (0.22) | 0.163 |
Revised AWGS | −0.27 (0.21) | 0.207 | −0.21 (0.21) | 0.316 |
EWGSOP 1 | −0.64 (0.22) | 0.004 | −0.58 (0.22) | 0.009 |
EWGSOP 2 | ||||
Sarcopenia | −0.32 (0.24) | 0.181 | −0.25 (0.24) | 0.299 |
Severe sarcopenia | −0.42 (0.27) | 0.127 | −0.30 (0.27) | 0.265 |
CMI | −0.41 (0.11) | <0.001 | −0.36 (0.11) | 0.001 |
Linear Regression Model 1 | Linear Regression Model 2 | Multivariate Logistic Regression Model 1 | Multivariate Logistic Regression Model 2 | |||
---|---|---|---|---|---|---|
Coefficients (SE) | p | Coefficients (SE) | p | Odds Ratio (95% CI) | Odds Ratio (95% CI) | |
Muscle mass index | 0.13 (0.10) | 0.207 | 0.09 (0.11) | 0.418 | 0.98 (0.84–1.15) | 1.01 (0.86–1.19) |
Hand grip | 0.03 (0.02) | 0.108 | 0.03 (0.02) | 0.078 | 0.98 (0.95–1.00) | 0.97 (0.95–1.00) |
Gait speed | 0.98 (0.38) | 0.009 | 0.81 (0.38) | 0.033 | 0.51 (0.28–0.90) | 0.54 (0.30–0.97) |
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Baek, J.-Y.; Lee, E.; Kim, W.J.; Jang, I.-Y.; Jung, H.-W. A Cumulative Muscle Index and Its Parameters for Predicting Future Cognitive Decline: Longitudinal Outcomes of the ASPRA Cohort. Int. J. Environ. Res. Public Health 2021, 18, 7350. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147350
Baek J-Y, Lee E, Kim WJ, Jang I-Y, Jung H-W. A Cumulative Muscle Index and Its Parameters for Predicting Future Cognitive Decline: Longitudinal Outcomes of the ASPRA Cohort. International Journal of Environmental Research and Public Health. 2021; 18(14):7350. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147350
Chicago/Turabian StyleBaek, Ji-Yeon, Eunju Lee, Woo Jung Kim, Il-Young Jang, and Hee-Won Jung. 2021. "A Cumulative Muscle Index and Its Parameters for Predicting Future Cognitive Decline: Longitudinal Outcomes of the ASPRA Cohort" International Journal of Environmental Research and Public Health 18, no. 14: 7350. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147350