Special Issue "Evolution of Antimicrobial Resistance and Balancing Antibiotics with Other Treatment Concepts"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".

Deadline for manuscript submissions: 1 August 2021.

Special Issue Editor

Dr. Manuel Antonio Rodríguez-Iglesias
Guest Editor
Department of Biomedicine, Biotechnology and Public Health, Universidad de Cádiz, Cadiz, Spain

Special Issue Information

Dear Colleague,

The emergence of multi-resistant bacteria is a global threat to public health, as declared by the WHO, which established its importance and urges measures for its control. The inappropriate use of antibiotics in humans and animals has led to the appearance of multiresistance that is difficult to control. Instead of new antibiotics, novel strategies have been proposed to fight bacterial pathogens, among which combinatorial therapy and the use of adjuvants. These adjuvants can include drugs used in clinical practice, such as monoclonal antibodies, beta-lactamase inhibitors, efflux pump inhibitors, or modulators of bacterial membrane potential. Virulence inhibitors, which, without causing selection pressure, can block virulence factors such as exotoxins and the ability to produce biofilm or can inhibit the mechanisms that control quorum sensing, are also being tested. There is a need for reprofiling or repositioning in drug development to allow new pharmacological uses of known drugs, different from their previous medical indications. Therefore, there is enormous interest in screening for drugs that may have anti-virulence effects. In this context, it is necessary to increase our knowledge to develop new antimicrobial treatment strategies.

The alternative use of molecules and strategies different from conventional antibiotics and treatments is exactly within the scope of Antibiotics and includes the search for new data and innovative approaches against multi-resistant bacteria. Although it may seem like a syntactic paradox, “non-antibiotics” are of enormous interest to scientific researchers in antibiotics.

Dr. Manuel Antonio Rodríguez-Iglesias
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • non-antibiotics
  • drug repositioning
  • antimicrobials
  • drug synergy
  • antibiotic resistance
  • biomimetic

Published Papers

This special issue is now open for submission.
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