Special Issue "Phytochemicals as Modulators of Oxidative Stress-Dependent, Inflammatory Conditions"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 May 2022.

Special Issue Editors

Prof. Dr. Luisa Tesoriere
E-Mail Website
Guest Editor
Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128 Palermo, Italy
Interests: nutraceuticals; bioactivity of natural products; betalain pigments; biochemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammation is a beneficial host response to foreign challenges or tissue injury, ultimately leading to the restoration of tissue structure and function. While the maintenance of physiological levels of oxidants is essential for life processes, an excessive oxidant challenge eventually starts signaling events involved in the development of a wide range of inflammatory conditions. Along these lines, it is becoming increasingly clear that a modulation of endogenous antioxidant defense mechanisms could represent an innovative therapeutic approach for inflammatory diseases. Originally considered ‘health-promoting’ by virtue of their radical-scavenging or direct antioxidant effects on cellular biomolecules, phytochemicals are now believed to effectively modulate the inflammatory response by intercepting reactive species at the level of critical signaling pathways.

The aim of this Special Issue is to bring together updated research on the modulation of oxidative stress-dependent inflammatory conditions by phytochemicals, both in vitro and in vivo. Moreover, studies on synergistic interactions between phytochemicals, interplay with pharmaceuticals, structure–activity relationships, and matrix and new delivery systems impact will also be considered. The molecular components within complex mixtures, responsible for the observed effects, should be identified and characterized. Authors are invited to submit manuscripts both in the form of original research and review articles.

Prof. Dr. Mario Allegra
Prof. Dr. Luisa Tesoriere
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Article
Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production
Antioxidants 2021, 10(8), 1215; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox10081215 - 28 Jul 2021
Cited by 1 | Viewed by 915
Abstract
Fisetin has numerous therapeutic properties, such as anti-inflammatory, antioxidative, and anticancer effects. However, the mechanism by which fisetin inhibits NLRP3 inflammasome remains unclear. In this study, we observed that fisetin bound to TLR4 and occluded the hydrophobic pocket of MD2, which in turn [...] Read more.
Fisetin has numerous therapeutic properties, such as anti-inflammatory, antioxidative, and anticancer effects. However, the mechanism by which fisetin inhibits NLRP3 inflammasome remains unclear. In this study, we observed that fisetin bound to TLR4 and occluded the hydrophobic pocket of MD2, which in turn inhibited the binding of LPS to the TLR4/MD2 complex. This prevented the initiation of scaffold formation by the inhibition of MyD88/IRAK4 and subsequently downregulated the NF-κB signaling pathway. The result also demonstrated that fisetin downregulated the activation of the NLRP3 inflammasome induced by LPS and ATP (LPS/ATP) and the subsequent maturation of IL-1β. Fisetin also activated mitophagy and prevented the accumulation of damaged mitochondria and the excessive production of mitochondrial reactive oxygen species. The transient knockdown of p62 reversed the inhibitory activity of fisetin on the LPS/ATP-induced formation of the NLRP3 inflammasome. This indicated that fisetin induces p62-mediated mitophagy for eliminating damaged mitochondria. Recently, the existence of inflammasomes in non-mammalian species including zebrafish have been identified. Treatment of an LPS/ATP-stimulated zebrafish model with fisetin aided the recovery of the impaired heart rate, decreased the recruitment of macrophage to the brain, and gradually downregulated the expression of inflammasome-related genes. These results indicated that fisetin inhibited the TLR4/MD2-mediated activation of NLRP3 inflammasome by eliminating damaged mitochondria in a p62-dependent manner. Full article
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