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10 pages, 34738 KiB

Open AccessArticle

Effect of Osteoporosis on Well-Integrated Bone Implants

by Amani M. Basudan, Marwa Y. Shaheen, Abdurahman A. Niazy, Jeroen J.J.P. van den Beucken, John A. Jansen and Hamdan S. Alghamdi

Appl. Sci. 2021, 11(2), 723; https://0-doi-org.brum.beds.ac.uk/10.3390/app11020723 - 13 Jan 2021

Cited by 4 | Viewed by 2327

Abstract

The installation of dental implants has become a common treatment for edentulous patients. However, concern exists about the influence of osteoporosis on the final implant success. This study evaluated whether an ovariectomy (OVX)-induced osteoporotic condition, induced eight weeks postimplantation in a rat femoral [...] Read more.

The installation of dental implants has become a common treatment for edentulous patients. However, concern exists about the influence of osteoporosis on the final implant success. This study evaluated whether an ovariectomy (OVX)-induced osteoporotic condition, induced eight weeks postimplantation in a rat femoral condyle, influences the bone response to already-integrated implants. The implants were inserted in the femoral condyle of 16 female Wistar rats. Eight weeks postimplantation, rats were randomly ovariectomized (OVX) or sham-operated (SHAM). Fourteen weeks later, animals were sacrificed, and implants were used for histological and histomorphometric analyses. A significant reduction in the quantity and quality of trabecular bone around dental implants existed in OVX rats in comparison to the SHAM group. For histomorphometric analysis, the bone area (BA%) showed a significant difference between OVX (34.2 ± 4.3) and SHAM (52.6 ± 12.7) groups (p < 0.05). Bone–implant contact (BIC%) revealed significantly lower values for all implants in OVX (42.5 ± 20.4) versus SHAM (59.0 ± 19.0) rats. Therefore, induction of an osteoporotic condition eight weeks postimplantation in a rat model negatively affects the amount of bone present in close vicinity to bone implants. Full article

(This article belongs to the Special Issue Implant Dentistry)

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11 pages, 2762 KiB

Open AccessArticle

Clinical Assessment of Dental Implants Placed in Low-Quality Bone Sites Prepared for the Healing Chamber with Osseodensification Concept: A Double-Blind, Randomized Clinical Trial

by Rafael Coutinho Mello-Machado, Carlos Fernando de Almeida Barros Mourão, Kayvon Javid, Henrique T. Ferreira, Pietro Montemezzi, Mônica Diuana Calasans-Maia and Plinio Mendes Senna

Appl. Sci. 2021, 11(2), 640; https://0-doi-org.brum.beds.ac.uk/10.3390/app11020640 - 11 Jan 2021

Cited by 6 | Viewed by 3341

Abstract

The present study aimed to compare the stability of dental implants placed in low-quality bone prepared for the healing chamber with osseodensification technique and a standard undersized drilling. Sixteen subjects presenting D3 or D4 bone density according to Misch’s classification were randomly distributed [...] Read more.

The present study aimed to compare the stability of dental implants placed in low-quality bone prepared for the healing chamber with osseodensification technique and a standard undersized drilling. Sixteen subjects presenting D3 or D4 bone density according to Misch’s classification were randomly distributed to receive dental implants following either osseodensification (G1: n = 29) or standard undersized drilling (G2: n = 26) preparation techniques. Implant insertion torque (IT) and implant stability quotient (ISQ) were measured immediately after implant placement. Implant survival and secondary stability (ISQ) were evaluated after six months. The G1 group showed higher IT (39.0 ± 6.4 Ncm) than G2 (32.0 ± 3.4 Ncm) (p < 0.001). ISQ values were similar (p > 0.05) at the implant insertion (67.1 ± 3.2 and 65.5 ± 2.7 for G1 and G2, respectively). After six months healing, implant survival was equally comparable in both groups (p > 0.05), and ISQ values were higher than those of implant insertion (p < 0.001) but similar (p > 0.05) for both groups (74.0 ± 3.6 and 73.3 ± 3.2 for G1 and G2, respectively). Within the limitations of this study, the present RCT demonstrated that a wider surgical bed prepared by osseodensification instrumentation allowed for the bone healing-chamber concept in low-quality bone without any reduction in implant stability and success rate. Full article

(This article belongs to the Special Issue Implant Dentistry)

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10 pages, 3363 KiB

Open AccessArticle

Validation of the Accuracy of Postoperative Analysis Methods for Locating the Actual Position of Implants: An In Vitro Study

by Se-Mok Oh and Du-Hyeong Lee

Appl. Sci. 2020, 10(20), 7266; https://0-doi-org.brum.beds.ac.uk/10.3390/app10207266 - 17 Oct 2020

Cited by 3 | Viewed by 2167

Abstract

Assessment of the accuracy of an implant guide system is essential, yet the reliability of postoperative methods for locating the implant position has still not been clarified. This study therefore sought to evaluate the accuracy of postoperative methods for locating the actual position [...] Read more.

Assessment of the accuracy of an implant guide system is essential, yet the reliability of postoperative methods for locating the implant position has still not been clarified. This study therefore sought to evaluate the accuracy of postoperative methods for locating the actual position of implants in terms of their linear and angular deviations. The implant position in a dentiform model was located using the following three methods: manual matching on a cone-beam computed tomography (CBCT) image (MC group), manual matching on a mesh model of CBCT (MM group), and automatic matching on a scan abutment of a scan image (AS group). Thirty clinicians adopted each method, and the estimated position of the implant in each group was compared three-dimensionally with the reference implant position using image analysis software in terms of the linear, vertical, and angular deviations. One-way analysis of variance (ANOVA) and Tukey’s post-hoc test were used for statistical analyses (α = 0.05). In general, the deviations were the largest in the MC group, followed by the MM group and the AS group. The ANOVA results suggested that all deviations values were markedly smaller in the AS group than in the MC group (p < 0.001). The interoperator measurement variability of all deviations was relatively smaller in the AS group than in the other two groups. The automatic matching method using scan abutments was more accurate than the manual matching methods using CBCT and mesh images in assessing the deviations that existed between the planned and actual positions of the implant. The use of scan abutments is recommended for the postoperative assessment of an implant’s placement location. Full article

(This article belongs to the Special Issue Implant Dentistry)

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13 pages, 2765 KiB

Open AccessArticle

Osseointegration of Maxillary Dental Implants in Diabetes Mellitus Patients: A Randomized Clinical Trial Human Histomorphometric Study

by Lyly Sam, Siriporn Chattipakorn and Pathawee Khongkhunthian

Appl. Sci. 2020, 10(19), 6762; https://0-doi-org.brum.beds.ac.uk/10.3390/app10196762 - 27 Sep 2020

Cited by 3 | Viewed by 3061

Abstract

Background: Survival of dental implants in well-controlled Type 2 diabetes (T2DM) was found to be comparable to that in healthy patients. However, to our best knowledge, there have been no studies of the bone histomorphometry of osseointegration in patients with Type 2 [...] Read more.

Background: Survival of dental implants in well-controlled Type 2 diabetes (T2DM) was found to be comparable to that in healthy patients. However, to our best knowledge, there have been no studies of the bone histomorphometry of osseointegration in patients with Type 2 diabetes. Purpose: To compare bone-implant-contact (BIC) and new bone formation between well-controlled Type 2 diabetes with HbA1c of less than 8% and healthy controls. Methods: 10 diabetic (T2DM) patients and 10 healthy controls were selected. Each patient received a 2.5 mm × 5 mm micro-implant in the maxilla, in either the premolar or first molar area. After 8 weeks of healing, the micro-implant was retrieved using a trephine bur and sent for bone histomorphometric analysis. A commercial titanium implant was immediately placed as the conventional treatment. Results: The mean BIC (30.73%) in T2DM patients was significantly lower than in the healthy patients (41.75%) (p = 0.01). New bone formation around the implant surface was reduced in T2DM patients (36.25%) compared to that in the control group (44.14%) (p = 0.028). The Pearson correlation coefficient revealed a strong correlation between increased HbA1c and decreased BIC (p < 0.05) and decreased new bone formation (p < 0.05). Conclusions: Within the limitation of this study, bone-to-implant contact and bone healing around dental implants in T2DM patients were significantly lower than in healthy patients. Full article

(This article belongs to the Special Issue Implant Dentistry)

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16 pages, 4560 KiB

Open AccessArticle

On the Use of a Simplified Slip Limit Equation to Predict Screw Self-Loosening of Dental Implants Subjected to External Cycling Loading

by Mikel Armentia, Mikel Abasolo, Ibai Coria and Abdel-Hakim Bouzid

Appl. Sci. 2020, 10(19), 6748; https://0-doi-org.brum.beds.ac.uk/10.3390/app10196748 - 26 Sep 2020

Cited by 7 | Viewed by 2711

Abstract

Self-loosening of the prosthetic screws is a major mechanical problem affecting roughly 10% of dental implants, according to the literature. This phenomenon may lead to micro-movements that produce crestal bone loss, peri-implantitis, or structural failure of the implant assembly. In this paper, a [...] Read more.

Self-loosening of the prosthetic screws is a major mechanical problem affecting roughly 10% of dental implants, according to the literature. This phenomenon may lead to micro-movements that produce crestal bone loss, peri-implantitis, or structural failure of the implant assembly. In this paper, a simple and effective tool to predict self-loosening under masticatory loads is presented. The loads acting on the screw are obtained from a simple finite element (FE) model, and introduced in a mathematical formula that calculates the torque needed to loosen the screw; self-loosening will occur when this torque becomes zero. In this sense, all the parameters involved in self-loosening phenomenon can be easily identified, and their effect quantified. For validating purposes, 90 experimental tests were performed in a direct stress test bench. As a result, a powerful tool with a maximum experimental error of 7.6% is presented, allowing dental implant manufacturers to predict eventual occurrence of self-loosening in their developed dental implant products and take corrective actions at preliminary design stage. Furthermore, the following clinical implications can be directly derived from the methodology: a higher screw preload, that is a higher tightening torque, improves self-loosening response of the dental implant and, similarly, for a given preload force, higher friction coefficient and screw metric, as well as lower pitch and thread angle values, are also found to be beneficial. Full article

(This article belongs to the Special Issue Implant Dentistry)

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16 pages, 2755 KiB

Open AccessArticle

Finite Element Analysis of the Stress Field in Peri-Implant Bone: A Parametric Study of Influencing Parameters and Their Interactions for Multi-Objective Optimization

by Paul Didier, Boris Piotrowski, Gael Le Coz, David Joseph, Pierre Bravetti and Pascal Laheurte

Appl. Sci. 2020, 10(17), 5973; https://0-doi-org.brum.beds.ac.uk/10.3390/app10175973 - 28 Aug 2020

Cited by 14 | Viewed by 4420

Abstract

The present work proposes a parametric finite element model of the general case of a single loaded dental implant. The objective is to estimate and quantify the main effects of several parameters on stress distribution and load transfer between a loaded dental implant [...] Read more.

The present work proposes a parametric finite element model of the general case of a single loaded dental implant. The objective is to estimate and quantify the main effects of several parameters on stress distribution and load transfer between a loaded dental implant and its surrounding bone. The interactions between them are particularly investigated. Seven parameters (implant design and material) were considered as input variables to build the parametric finite element model: the implant diameter, length, taper and angle of inclination, Young’s modulus, the thickness of the cortical bone and Young’s modulus of the cancellous bone. All parameter combinations were tested with a full factorial design for a total of 512 models. Two biomechanical responses were identified to highlight the main effects of the full factorial design and first-order interaction between parameters: peri-implant bone stress and load transfer between bones and implants. The description of the two responses using the identified coefficients then makes it possible to optimize the implant configuration in a case study with type IV. The influence of the seven considered parameters was quantified, and objective information was given to support surgeon choices for implant design and placement. The implant diameter and Young’s modulus and the cortical thickness were the most influential parameters on the two responses. The importance of a low Young’s modulus alloy was highlighted to reduce the stress shielding between implants and the surrounding bone. This method allows obtaining optimized configurations for several case studies with a custom-made design implant. Full article

(This article belongs to the Special Issue Implant Dentistry)

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16 pages, 4604 KiB

Open AccessArticle

Biomechanical Design Application on the Effect of Different Occlusion Conditions on Dental Implants with Different Positions—A Finite Element Analysis

by Pei-Ju Lin and Kuo-Chih Su

Appl. Sci. 2020, 10(17), 5826; https://0-doi-org.brum.beds.ac.uk/10.3390/app10175826 - 23 Aug 2020

Cited by 13 | Viewed by 6275

Abstract

A dental implant is currently the most commonly used treatment for patients with lost teeth. There is no biomechanical reference available to study the effect of different occlusion conditions on dental implants with different positions. Therefore, the aim of this study was to [...] Read more.

A dental implant is currently the most commonly used treatment for patients with lost teeth. There is no biomechanical reference available to study the effect of different occlusion conditions on dental implants with different positions. Therefore, the aim of this study was to conduct a biomechanical analysis of the impact of four common occlusion conditions on the different positions of dental implants using the finite element method. We built a finite element model that included the entire mandible and implanted seven dental implant fixtures. We also applied external force to the position of muscles on the mandible of the superficial masseter, deep masseter, medial pterygoid, anterior temporalis, middle temporalis, and posterior temporalis to simulate the four clenching tasks, namely the incisal clench (INC), intercuspal position (ICP), right unilateral molar clench (RMOL), and right group function (RGF). The main indicators measured in this study were the reaction force on the temporomandibular joint (TMJ) and the fixed top end of the abutment in the dental implant system, and the stress on the mandible and dental implant systems. The results of the study showed that under the occlusion conditions of RMOL, the dental implant system (113.99 MPa) and the entire mandible (46.036 MPa) experienced significantly higher stress, and the reaction force on the fixed-top end of the abutment in the dental implant system (261.09 N) were also stronger. Under the occlusion of ICP, there was a greater reaction force (365.8 N) on the temporomandibular joint. In addition, it was found that the reaction force on the posterior region (26.968 N to 261.09 N) was not necessarily greater than that on the anterior region (28.819 N to 70.431 N). This information can help clinicians and dental implant researchers understand the impact of different chewing forces on the dental implant system at different positions after the implantation. Full article

(This article belongs to the Special Issue Implant Dentistry)

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12 pages, 1676 KiB

Open AccessArticle

Modeling of Dental Implant Osseointegration Progress by Three-Dimensional Finite Element Method

by Iulia Roatesi and Simona Roatesi

Appl. Sci. 2020, 10(16), 5561; https://0-doi-org.brum.beds.ac.uk/10.3390/app10165561 - 11 Aug 2020

Cited by 2 | Viewed by 2489

Abstract

As osseointegration is a time-dependent process, biomechanical assessment is thought to determine whether a fibrous encapsulation or a bone covering will develop around an implant, according to the stress in the implant and surrounding bone. This study proposes a model for stress evaluation [...] Read more.

As osseointegration is a time-dependent process, biomechanical assessment is thought to determine whether a fibrous encapsulation or a bone covering will develop around an implant, according to the stress in the implant and surrounding bone. This study proposes a model for stress evaluation by finite element method (FEM) during the osseointegration progress, the main factor implied in implant success or failure. The loadings due to masticatory forces generate stress concentration and consequently, an adequate risk concerning the implant stability should be assessed. An accurate FEM model is used to calculate the stress and displacement in the whole implant–bone system during the osseointegration progress. This process is simulated by taking into account the gradual increase in the damaged biomechanical properties of the cortical bone. The results reveal that as the implant osseointegration occurs gradually, the bone stiffness from the peri-implant area increases gradually, such that in the end (healing) we observed that the cortical bone begins to take over the bending loading. In addition, the displacements decrease as the osseointegration gradually occurs and the cortical bone stress reaches higher values, which are placed in the mandibular ridge. The FEM is suitable to model the osseointegration progress, offering valuable information concerning the stress concentration zones in the implant–bone system and consequently, the risk evaluation, both for pre- and post-osseointegration. Full article

(This article belongs to the Special Issue Implant Dentistry)

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13 pages, 1916 KiB

Open AccessArticle

Allogeneic Demineralized Dentin Matrix Graft for Guided Bone Regeneration in Dental Implants

by In-Woong Um, Jeong-Kui Ku, Yu-Mi Kim, Pil-Young Yun, Na-Hee Chang, Young-Kyun Kim and Yonghoon Choi

Appl. Sci. 2020, 10(13), 4661; https://0-doi-org.brum.beds.ac.uk/10.3390/app10134661 - 7 Jul 2020

Cited by 16 | Viewed by 4680

Abstract

Autogenous and allogeneic demineralized dentin matrices (Auto-DDM and Allo-DDM, respectively) are currently used for guided bone regeneration (GBR). Buccal marginal bone (BMB) resorption is critical for successful implant integration. This study analyzed BMB resorption around dental implants for GBR between the control group [...] Read more.

Autogenous and allogeneic demineralized dentin matrices (Auto-DDM and Allo-DDM, respectively) are currently used for guided bone regeneration (GBR). Buccal marginal bone (BMB) resorption is critical for successful implant integration. This study analyzed BMB resorption around dental implants for GBR between the control group (Auto-DDM graft) and experimental group (Allo-DDM graft). From 2014 to 2019, we enrolled 96 patients (59 males, 37 females, average 57.13 years) who received GBR (52 and 44 using Allo-DDM and Auto-DDM, respectively,) without a barrier membrane and a simultaneous single dental implantation (54 in the maxilla and 42 in the mandible). BMB height was measured immediately after GBR, at prosthetic loading, and 12 months after loading. BMB resorption was classified as initial resorption (between GBR and prosthetic loading) and functional resorption (during 12 months after prosthetic loading). The differences in the BMB levels of Auto-DDM and Allo-DDM were analyzed between the initial and functional resorption stages by independent sample t-test. Auto-DDM and Allo-DDM showed similar BMB changes in initial resorption (0.73 ± 0.97 and 0.72 ± 0.77 mm, respectively) and functional resorption (0.69 ± 0.81 and 0.48 ± 0.58 mm, respectively) without a significant difference between the maxilla and mandible. For GBR, Allo-DDM is comparable to Auto-DDM in terms of BMB resorption. Full article

(This article belongs to the Special Issue Implant Dentistry)

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13 pages, 3742 KiB

Open AccessArticle

Biological Effect of Single or Combined Pharmacological Therapy Using Alendronate and Simvastatin on Implant Osseointegration: An In Vivo Study in Healthy and Osteoporotic Rat Models

by Amani M. Basudan, Marwa Y. Shaheen, Abdurahman A. Niazy, Jeroen J.J.P. van den Beucken, John A. Jansen and Hamdan S. Alghamdi

Appl. Sci. 2020, 10(12), 4298; https://0-doi-org.brum.beds.ac.uk/10.3390/app10124298 - 23 Jun 2020

Cited by 1 | Viewed by 2035

Abstract

To evaluate peri-implant bone formation following single or combined systemic administration of alendronate and simvastatin in healthy and osteoporotic rats, eighty female Wistar rats were ovariectomized (n = 40) or sham-operated (n = 40). At six weeks, implants were placed in femoral condyles. [...] Read more.

To evaluate peri-implant bone formation following single or combined systemic administration of alendronate and simvastatin in healthy and osteoporotic rats, eighty female Wistar rats were ovariectomized (n = 40) or sham-operated (n = 40). At six weeks, implants were placed in femoral condyles. Then, ovariectomized (OVX) and sham-operated (SHAM) animals received daily subcutaneous alendronate (50 µg/kg), simvastatin (5 mg/kg), or both, for three weeks. Control animals received subcutaneous saline. Thereafter, specimens were retrieved for biomechanical testing, histological evaluation, and bone area (BA%) and bone-to-implant contact (BIC%). In healthy and osteoporotic rats, similar (p > 0.05) push-out values were observed for all groups. For BA% analysis, control rats showed similar results for OVX (9.2% ± 2.4%) and SHAM (11.1% ± 3.5%) animals. In contrast, single or combined drug therapy significantly increased BA% compared to controls in both healthy and osteoporotic conditions (p < 0.05). In osteoporotic conditions, alendronate alone showed a superior effect on BA% compared to simvastatin alone, or their combination. Systemic alendronate, simvastatin, or both showed a similar BIC% compared to controls (p > 0.05). The present study demonstrates that single or combined systemic alendronate and simvastatin increases bone formation around implants (i.e., distance osteogenesis) in healthy and osteoporotic bone conditions. However, these drugs showed no beneficial effect on direct bone-to-implant contact or implant fixation. Full article

(This article belongs to the Special Issue Implant Dentistry)

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9 pages, 1917 KiB

Open AccessArticle

Biomechanical Evaluation of the Effects of Implant Neck Wall Thickness and Abutment Screw Size: A 3D Nonlinear Finite Element Analysis

by Ming-Dih Jeng, Yang-Sung Lin and Chun-Li Lin

Appl. Sci. 2020, 10(10), 3471; https://0-doi-org.brum.beds.ac.uk/10.3390/app10103471 - 18 May 2020

Cited by 14 | Viewed by 4195

Abstract

In this study, we evaluate the influence of implant neck wall thickness and abutment screw size on alveolar bone and implant component biomechanical responses using nonlinear finite element (FE) analysis. Twelve internal hexagon Morse taper implant–abutment connection FE models with three different implant [...] Read more.

In this study, we evaluate the influence of implant neck wall thickness and abutment screw size on alveolar bone and implant component biomechanical responses using nonlinear finite element (FE) analysis. Twelve internal hexagon Morse taper implant–abutment connection FE models with three different implant sizes (diameters 4, 5, and 6 mm), secured with 1.4, 1.6, and 1.8 mm abutment screws to fit with three unilateral implant neck wall thicknesses of 0.45, 0.50, and 1.00 mm, were constructed to perform simulations. Nonlinear contact elements were used to simulate realistic interface fixation within the implant system. A 200 N concentrated force was applied toward the center of a hemispherical load cap and inclined 30° relative to the implant axis as the loading condition. The simulation results indicated that increasing the unilateral implant neck wall thickness from 0.45 to 1.00 mm can significantly decrease implant, abutment, and abutment screw stresses and bone strain, decreased to 58%, 48%, 54%, and 70%, respectively. Variations in abutment screw size only significantly influenced abutment screw stress, and the maximum stress dissipation rates were 10% and 29% when the diameter was increased from 1.4 to 1.6 and 1.8 mm, respectively. We conclude that the unilateral implant neck wall thickness is the major design factor for the implant system and implant neck wall thickness in effectively decreasing implant, abutment, and abutment screw stresses and bone strain. Full article

(This article belongs to the Special Issue Implant Dentistry)

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12 pages, 2174 KiB

Open AccessArticle

The Effect of Insertion Angles and Depths of Dental Implant on the Initial Stability

by Hsiang-Chun Wu, Ming-Tzu Tsai and Jui-Ting Hsu

Appl. Sci. 2020, 10(9), 3112; https://0-doi-org.brum.beds.ac.uk/10.3390/app10093112 - 29 Apr 2020

Cited by 5 | Viewed by 4210

Abstract

The objective of this study was to evaluate the effect of the measurement directions of the Periotest value (PTV) and implant stability quotient (ISQ) of dental implant fixtures inserted at various angles and depths. Five groups were organized: vertically inserted implants in an [...] Read more.

The objective of this study was to evaluate the effect of the measurement directions of the Periotest value (PTV) and implant stability quotient (ISQ) of dental implant fixtures inserted at various angles and depths. Five groups were organized: vertically inserted implants in an evencrestal position; implants inserted at a 17° tilt in a distal subcrestal position; implants inserted at a 17° tilt in a mesial supracrestal position; implants inserted at a 30° tilt in a distal subcrestal position; and implants inserted at a 30° tilt in a mesial supracrestal position. The PTV and ISQ were measured along four directions (buccal, lingual, mesial, and distal directions) in all specimens. The PTV and ISQ exhibited a highly negative correlation when the fixture was vertically inserted. Compared to the implants inserted vertically and at the distal subcrestal position, the fixture with a greater tilt and inserted at the mesial supracrestal position had a lower stability. The PTV and ISQ of the tilted implants were affected by the measurement direction, inserted angulation and depth. Full article

(This article belongs to the Special Issue Implant Dentistry)

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Review

Jump to: Research

16 pages, 479 KiB

Open AccessReview

Does Platelet-Rich Fibrin Decrease Dimensional Changes and Improve Postoperative Comfort in Post-Extraction Sockets? An Overview of Systematic Reviews

by Vittorio Moraschini, Carlos Fernando de Almeida Barros Mourão, Rafael Coutinho de Mello Machado, Jhonathan Raphaell Barros Nascimento, Kayvon Javid, Monica Diuana Calasans-Maia, Angelo Cardarelli, Pietro Montemezzi and Jose de Albuquerque Calasans-Maia

Appl. Sci. 2020, 10(17), 5750; https://0-doi-org.brum.beds.ac.uk/10.3390/app10175750 - 20 Aug 2020

Cited by 4 | Viewed by 2032

Abstract

This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and [...] Read more.

This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and alveolar osteitis after tooth extraction. An electronic search without date or language restriction was done in PubMed/MEDLINE, Cochrane, and Web of Science until March 2020. Eligibility criteria included SRs that assessed the effect of PRF for human alveolar socket preservation. The quality assessment of the included studies was performed using AMSTAR 2 guidelines. The protocol of this overview was recorded in PROSPERO under the number CRD42018089617. The search and selection process yielded 13 studies published between 2011 and 2018. The analysis of the studies showed inconclusive data for the effect of the PRF and the dimensional changes. There is no definitive evidence for the impact of using PRF alone on bone regeneration in post-extraction sockets. The use of PRF improves soft tissue healing and reduces pain, bleeding, and osteitis in post-extraction sockets. Full article

(This article belongs to the Special Issue Implant Dentistry)

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