Dear Colleagues,

Psoriasis is an inflammatory and immune-mediated skin disease first discovered by the medical community in the early 19th century. Researchers have learned much about psoriasis since, although the condition has a long history of misunderstandings.

Nowadays, the increased knowledge about the pathogenesis and comorbidities of psoriasis has contributed to a new understanding of psoriasis as a systemic disease. At the same time, the identification of specific molecular targets has led to the emergence of a variety of modern treatments able to significantly reduce the severity of the disease and sometimes change its natural history.

The therapeutic management of psoriatic patients has changed profoundly over the last century, evolving from an exclusively topical approach to one more oriented towards the containment of systemic inflammation.

The advent of target treatments has radically changed the therapeutic management of psoriatic patients, and the initial doubts about the safety profile of these drugs in the long term have been definitively dispelled.

This Special Issue provides a concise overview of the long history of clinicians’ understanding of psoriasis and its treatments.

Dr. Anna Campanati
Dr. Giulia Radi
Dr. Emanuela Martina
Dr. Federico Diotallevi
Guest Editors

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• psoriasis
• natural history
• biologics
• topical treatment
• small molecules
• pathogenesis
• systemic treatments