ijms-logo

Journal Browser

Journal Browser

Skin, Autoimmunity and Inflammation 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 4677

Special Issue Editors


E-Mail Website
Guest Editor
Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, Italy
Interests: skin immune-mediated skin diseases; psoriasis; suppurative hidradenitis; chronic urticaria; atopic dermatitis; adnexal diseases; melanoma and non-melanoma skin cancer; scleroderma
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Dermatology Unit, Polytechnic Marche University, Ancona, Italy
Interests: psoriasis; clinical dermatology; pediatric dermatology; skin inflammation; melanoma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue “Skin, Autoimmunity and Inflammation”.

The skin is the largest organ in the body and a site where a multitude of cell types interact, performing plastic and dynamic cellular communication in order to maintain various vital processes such as inflammation, immune responses including tolerance induction and disease prevention, wound healing, and angiogenesis. Of paramount importance are the immunological functions of the skin that protect against harmful exposure to external and internal environments. However, in some skin diseases, this complex mechanism of cellular interactions is altered and knowledge of the molecules pivotal to these alterations is of fundamental importance for the creation of appropriate drugs. The aim of this Special Issue is to analyze inflammatory and autoimmune skin diseases and focus on the molecular targets of the most recent pharmacological treatments.

Prof. Dr. Annamaria Offidani
Dr. Federico Diotallevi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin diseases
  • skin immunology
  • skin autoimmunity
  • skin inflammation
  • inflammatory cytokines
  • biological therapies
  • immunotherapy
  • target therapies

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

25 pages, 6954 KiB  
Review
The Pathophysiology and Treatment of Pyoderma Gangrenosum—Current Options and New Perspectives
by Magdalena Łyko, Anna Ryguła, Michał Kowalski, Julia Karska and Alina Jankowska-Konsur
Int. J. Mol. Sci. 2024, 25(4), 2440; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25042440 - 19 Feb 2024
Viewed by 1113
Abstract
Pyoderma gangrenosum (PG) is an uncommon inflammatory dermatological disorder characterized by painful ulcers that quickly spread peripherally. The pathophysiology of PG is not fully understood; however, it is most commonly considered a disease in the spectrum of neutrophilic dermatoses. The treatment of PG [...] Read more.
Pyoderma gangrenosum (PG) is an uncommon inflammatory dermatological disorder characterized by painful ulcers that quickly spread peripherally. The pathophysiology of PG is not fully understood; however, it is most commonly considered a disease in the spectrum of neutrophilic dermatoses. The treatment of PG remains challenging due to the lack of generally accepted therapeutic guidelines. Existing therapeutic methods focus on limiting inflammation through the use of immunosuppressive and immunomodulatory therapies. Recently, several reports have indicated the successful use of biologic drugs and small molecules administered for coexisting diseases, resulting in ulcer healing. In this review, we summarize the discoveries regarding the pathophysiology of PG and present treatment options to raise awareness and improve the management of this rare entity. Full article
(This article belongs to the Special Issue Skin, Autoimmunity and Inflammation 2.0)
Show Figures

Figure 1

31 pages, 1962 KiB  
Review
Inflammation and Psoriasis: A Comprehensive Review
by Alessandra-Mădălina Man, Meda Sandra Orăsan, Oana-Alina Hoteiuc, Maria-Cristina Olănescu-Vaida-Voevod and Teodora Mocan
Int. J. Mol. Sci. 2023, 24(22), 16095; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms242216095 - 08 Nov 2023
Cited by 4 | Viewed by 3259
Abstract
Psoriasis is an immune-mediated disease with a strong genetic component that brings many challenges to sick individuals, such as chronic illness, and which has multiple associated comorbidities like cardiovascular disease, metabolic syndrome, inflammatory bowel disease, and psychological disorders. Understanding the interplay between the [...] Read more.
Psoriasis is an immune-mediated disease with a strong genetic component that brings many challenges to sick individuals, such as chronic illness, and which has multiple associated comorbidities like cardiovascular disease, metabolic syndrome, inflammatory bowel disease, and psychological disorders. Understanding the interplay between the innate and adaptative immune system has led to the discovery of specific cytokine circuits (Tumor Necrosis Factor-alpha (TNF-α), IL-23, IL-17), which has allowed scientists to discover new biomarkers that can be used as predictors of treatment response and pave the way for personalized treatments. In this review, we describe the footprint psoriasis leaves on the skin and beyond, key pathophysiological mechanisms, current available therapeutic options, and drawbacks faced by existing therapies, and we anticipate potential future perspectives that may improve the quality of life of affected individuals. Full article
(This article belongs to the Special Issue Skin, Autoimmunity and Inflammation 2.0)
Show Figures

Figure 1

Back to TopTop