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Biomedicines
Special Issues
Metabolism, Target and Delivery of Anticancer Drugs
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Metabolism, Target and Delivery of Anticancer Drugs

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5933

Special Issue Editors

Prof. Dr. Zhi Shi

E-Mail Website
Guest Editor
Department of Cell Biology & Institute of Biomedicine, Jinan University, Guangzhou, China
Interests: cancer cell biology; cancer pharmacology
Prof. Dr. Meiwan Chen

E-Mail Website
Guest Editor
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau
Interests: molecular pharmaceutics; biomaterial and nanomedicine

Special Issue Information

Dear Colleagues,

Drug metabolism is the chemical alteration of a drug by the body. Drugs could be further metabolized and achieve therapeutic function in the body, and subsequently, metabolites are excreted. Drug target is a molecule in the body, usually a protein, which plays a key regulatory role in disease processes and that could be an effective therapeutic target. Drug delivery is a process of administering a pharmaceutical compound to enhance pharmacokinetic properties of drugs, minimize harmful side effects, and bring about superior clinical outcomes. Illuminating new mechanisms of drug metabolism and discovering novel drug targets and delivery technologies is expected to improve the therapeutic effect of various diseases, especially cancer.

We welcome submissions on the metabolism, target, and delivery of anticancer drugs. Novel findings contributing to our understanding of all aspects on metabolism, target, and delivery of anticancer drugs are encouraged for submission to this Special Issue.

In this Special Issue, original research articles and reviews are welcome. We look forward to receiving your contributions.

Prof. Dr. Zhi Shi
Prof. Dr. Meiwan Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug metabolism
  • target
  • therapy

Published Papers (2 papers)

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Research

12 pages, 3926 KiB  
Article
GSK2606414 Sensitizes ABCG2-Overexpressing Multidrug-Resistant Colorectal Cancer Cells to Chemotherapeutic Drugs
by Ze-Zhong Yu, Bu-Qing Xu, Ying-Ying Wang, Peng-Wei Zhang, Yu-Bin Shu and Zhi Shi
Biomedicines 2023, 11(11), 3103; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines11113103 - 20 Nov 2023
Viewed by 998
Abstract
Colorectal cancer is a common malignant tumor. A major factor in the high mortality rate of colorectal cancer is the emergence of multidrug resistance (MDR). Overexpression of the ABCG2 gene in cancer cells directly leads to MDR. Finding new inhibitors of ABCG2 may [...] Read more.
Colorectal cancer is a common malignant tumor. A major factor in the high mortality rate of colorectal cancer is the emergence of multidrug resistance (MDR). Overexpression of the ABCG2 gene in cancer cells directly leads to MDR. Finding new inhibitors of ABCG2 may be an effective way to overcome drug resistance. We found that the compound GSK2606414 enhanced the sensitivity of the ABCG2 substrate to the chemotherapeutic drugs mitoxantrone and doxorubicin in ABCG2-overexpressing multidrug-resistant colorectal cancer cells by increasing their intracellular accumulation without affecting the protein expression of ABCG2. Molecular docking experiments predicted that GSK2606414 could stably bind in the drug-binding pocket of ABCG2. In conclusion, GSK2606414 can sensitize ABCG2-overexpressed multidrug-resistant colorectal cancer cells to chemotherapy drugs and can be used as a potential inhibitor of ABCG2. Full article
(This article belongs to the Special Issue Metabolism, Target and Delivery of Anticancer Drugs)
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14 pages, 3622 KiB  
Article
Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma
by Jiyan Wang, Yaya Qiao, Huanran Sun, Hongkai Chang, Huifang Zhao, Shuai Zhang and Changliang Shan
Biomedicines 2022, 10(2), 234; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10020234 - 22 Jan 2022
Cited by 13 | Viewed by 3891
Abstract
Tyrosine is an essential ketogenic and glycogenic amino acid for the human body, which means that tyrosine is not only involved in protein metabolism, but also participates in the metabolism of lipids and carbohydrates. The liver is an important place for metabolism of [...] Read more.
Tyrosine is an essential ketogenic and glycogenic amino acid for the human body, which means that tyrosine is not only involved in protein metabolism, but also participates in the metabolism of lipids and carbohydrates. The liver is an important place for metabolism of lipids, carbohydrates, and proteins. The metabolic process of biological macro-molecules is a basis for maintaining the physiological activities of organisms, but the cross-linking mechanism of these processes is still unclear. Here, we found that the tyrosine-metabolizing enzymes, which were specifically and highly expressed in the liver, were significantly down-regulated in hepatocellular carcinoma (HCC), and had a correlation with a poor prognosis of HCC patients. Further analysis found that the reduction of tyrosine metabolism would activate the cell cycle and promote cell proliferation. In addition, we also found that the solute carrier family 27 member 5 (SLC27A5) regulates the expression of tyrosine-metabolizing enzymes through nuclear factor erythroid 2-related factor 2 (NRF2). Therefore, the SLC27A5 and tyrosine-metabolizing enzymes that we have identified coordinate lipid and tyrosine metabolism, regulate the cell cycle, and are potential targets for cancer treatment. Full article
(This article belongs to the Special Issue Metabolism, Target and Delivery of Anticancer Drugs)
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