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Special Issue Editors

Prof. Dr. Shea Ping Yip

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Guest Editor

Department of Health Technology and Informatics (HTI), The Hong Kong Polytechnic University, Kowloon, Hong Kong
Interests: molecular diagnostics; functional genomics

Dr. Chien-Ling Huang

E-Mail Website
Guest Editor

Department of Health Technology and Informatics (HTI), The Hong Kong Polytechnic University, Kowloon, Hong Kong
Interests: molecular diagnostics; functional genomics

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to bring together international experts to provide a comprehensive overview of and recent advances in the dynamic research field of “Non-Coding RNA as a Promising Biomarker for Disease Diagnosis and Prognosis”. Therefore, we invite you to participate with either an original article or a review focused on the following and other aspects:

Non-coding RNA identification and detection;
Molecular diagnosis of cancer and complex disease;
Prognosis markers for infectious disease;
Bioinformatics and experimental approaches targeting the network interactome;
Delivery and therapeutic methods

Prof. Dr. Shea Ping Yip
Dr. Chien-Ling Huang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

non-coding RNA
biomarker
molecular diagnosis
cancer
complex disease
infectious disease
bioinformatics
therapeutic delivery

Published Papers (2 papers)

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Research

Jump to: Review

14 pages, 2766 KiB

Open AccessCommunication

Expression of Apoptosis-Related Biomarkers in Inflamed Nasal Sinus Epithelium of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)—Evaluation at mRNA and miRNA Levels

by Monika Morawska-Kochman, Agnieszka Śmieszek, Klaudia Marcinkowska, Krzysztof Mariusz Marycz, Kamil Nelke, Krzysztof Zub, Tomasz Zatoński and Marek Bochnia

Biomedicines 2022, 10(6), 1400; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10061400 - 13 Jun 2022

Cited by 8 | Viewed by 1950

Abstract

In chronic upper respiratory tract diseases, increased cell proliferative activity is observed, which is coordinated by BCL-2 proteins and small non-coding RNAs. This study aimed to determine the expression of critical apoptosis markers at the mRNA and miRNA levels in patients with chronic rhinosinusitis with nasal polyps (CSRwNP). The study group consisted of ten patients with CSRwNP and ten healthy subjects. To detect in situ apoptosis in the maxillary sinus mucosa, TUNEL staining was performed. The expression of transcripts was determined by RT-qPCR and included the detection of markers associated with cell survival and apoptosis, i.e., BAX, p53, p21, CASP3, CASP9, c-MYC, CCND1, BRIC5, and APAF1. Levels of miR-17-5p, miR-145-5p, miR-146a-5p, and miR-203a-3p were also measured by RT-qPCR. The obtained results indicated increased apoptosis determined by a TUNEL assay in CSRwNP patients and accompanied by an increased expression of BAX, P21, P53, CASP3, CASP9, c-MYC, and APAF-1 transcripts and decreased mRNA levels of BCL-2 and BIRC5. Furthermore, the nasal sinus epithelium of patients with CSRwNP showed increased levels of miR-203a-3p while also showing a decreased expression of miR-17-5p and miR-145-5p. Our results showed that pro-apoptotic transcripts detected at mRNA and miRNA levels might be involved in the pathogenesis of chronic sinusitis with polyps. The identification of those key molecular mediators may be applicable for the specific diagnostic and/or development of targeted therapies for chronic sinusitis with polyps. Full article

(This article belongs to the Special Issue Non-coding RNA as Promising Biomarker for Disease Diagnosis and Prognosis)

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Review

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23 pages, 2421 KiB

Open AccessReview

Stressing the Regulatory Role of Long Non-Coding RNA in the Cellular Stress Response during Cancer Progression and Therapy

by Yi-Zhen Wu, Yong-Han Su and Ching-Ying Kuo

Biomedicines 2022, 10(5), 1212; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10051212 - 23 May 2022

Cited by 3 | Viewed by 2503

Abstract

Cellular stress response is an important adaptive mechanism for regulating cell fate decision when cells confront with stress. During tumorigenesis, tumor progression and the course of treatment, cellular stress signaling can activate subsequent response to deal with stress. Therefore, cellular stress response has impacts on the fate of tumor cells and tumor responsiveness relative to therapeutic agents. In recent years, attention has been drawn to long non-coding RNAs (lncRNAs), a novel class of RNA molecules with more than 200 nucleotides in length, which has little protein-coding potential and possesses various functions in multiple biological processes. Accumulating evidence has shown that lncRNAs are also engaged in the regulation of cellular stress response, particularly in cancers. Here, we summarize lncRNAs that have been reported in the adaptive response to major types of cellular stress including genotoxic, hypoxic, oxidative, metabolic and endoplasmic reticulum stress, all of which are often encountered by cancer cells. Specifically, the molecular mechanisms of how lncRNAs regulate cellular stress response during tumor progression or the development of therapy resistance are emphasized. The potential clinical applications of stress-responsive lncRNAs as biomarkers will also be discussed. Full article

(This article belongs to the Special Issue Non-coding RNA as Promising Biomarker for Disease Diagnosis and Prognosis)

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