Dear Colleagues,

The immune system is an intricated, combined functional cluster of structures, tissues, cells, and cell products with a mission that is to differentiate self from non-self. It allows it to protect the organism from potentially pathogenic agents or substances, but also it is important for them to recognize and respect own organs.

Epigenetic mechanisms are a key element for immune system to develop and enable an adequate gene expression pattern of their cells. Moreover, pathogenic factors (infections, tumoral transformed cells, toxic compounds) that this immune system can be exposed to, might be considered some kind of environmental pressure that also induces additional epigenetic changes to adapt to those novel elements and control them.

Health and disease in humans are not a black and white picture. During life, complex interactions between genetics, time (and aging), risk factors and deleterious exposures, system responses (adapted or not) and a little luck (or not) can be combined. All these are factors that are found to induce epigenetic changes of different cellular structures to adapt (included the immune system).

For this Special Issue, we are inviting manuscripts where epigenetic changes of immune system are described: ontogenic development of their cells, but also as part of immune response in infections or immunosurveillance, autoimmunity, inflammation activity or immune senescence. The interest that these mechanisms have is broad, such as being able to respond to pathophysiological mechanisms that are still little known, identify new therapeutic targets or even as diagnostic or susceptibility markers for the development of diseases.

Dr. Juan Luis Fernandez-Morera
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• immune system
• autoimmunity
• immunosurveillance
• inflammation
• immunosenescence
• immunological tolerance