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Oral Cancer and Oral Potentially Malignant Disorders: Evidence and Advances

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A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Oral Health".

Deadline for manuscript submissions: closed (11 April 2023) | Viewed by 12029

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Special Issue Editor

Dr. Pablo Ramos-Garcia

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Guest Editor

Oral Medicine & Pathology, School of Dentistry, University of Granada, 18071 Granada, Spain
Interests: oral medicine; oral pathology; head and neck oncology; oral cancer; prognosis; molecular biomarkers; targeted therapy; chromosomal band 11q13; CCND1/cyclin D1; oral potentially malignant disorders; oral lichen planus; malignant transformation; dentistry; dental anthropology; oral health; systematic review; meta-analysis

Special Issue Information

Dear Colleagues,

Oral cancer is a growing global public health problem, with 354,864 new cases and 177,384 deaths a year (GLOBOCAN, IARC, WHO). Oral squamous cell carcinoma represents around 90% of malignant oral neoplasms and has a 5-year survival rate of 50–60%. Although the oral cavity is easily accessible for clinical examinations, oral cancer is frequently diagnosed at a late stage, with poor prognosis and a lower quality of life for patients. Tobacco, alcohol, and human papillomavirus infection are currently considered the most important risk factors for oral cancer, but emergent environmental factors (e.g., diet) could also play a role in its etiopathogenesis. Oral cancer is often preceded by oral potentially malignant disorders, which include a group of mucosal lesions and conditions (e.g., leukoplakia, erythroplakia, lichen planus, or oral submucous fibrosis) whose malignant transformation risk is currently unpredictable and evaluated according to the presence and severity of epithelial dysplasia.

The aim of this Special Issue is to contribute to the dissemination of basic, translational, or clinical research through high-quality original papers and reviews relating to the epidemiology, etiopathogenesis, prevention, diagnosis, clinical features, prognosis, therapy, and/or management of patients with oral potentially malignant disorders or oral cancer.

Dr. Pablo Ramos-Garcia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Oral cancer
Oral potentially malignant disorders
Oral lichen planus
Leukoplakia
Erythroplakia
Oral submucous fibrosis
Oral medicine
Oral pathology

Published Papers (4 papers)

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Research

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12 pages, 1277 KiB

Open AccessArticle

Synergistic Efficacy of Plaque Control with Intralesional Triamcinolone Acetonide Injection on Erosive Non-Gingival Oral Lichen Planus: A Randomized Controlled Clinical Trial

by Wei Zhao, Duanxian Lin, Shuzhi Deng, Shimeng Wang, Yiqing Guo, Jin Yang, Xueke Shi and Hongmei Zhou

Int. J. Environ. Res. Public Health 2022, 19(21), 13787; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph192113787 - 23 Oct 2022

Cited by 1 | Viewed by 1476

Abstract

This study is the first time to assess the synergistic efficacy and safety of plaque control on erosive non-gingival oral lichen planus (OLP). A randomized, controlled, clinical trial with blind evaluation was designed, and 48 OLP patients with erosive non-gingival OLP lesions were randomly assigned to the experimental group (n = 25, receiving intralesional triamcinolone acetonide injection, periodontal scaling, and oral hygiene instruction) and the control group (n = 23, only receiving intralesional triamcinolone acetonide injection) once a week for 2 weeks. Erosion size, pain level, plaque index, and community periodontal index were measured at every visit. Patients cured of erosion were followed up for 3 months to evaluate the recurrence rate. Adverse reactions were also recorded. At day 14 ± 2, the experimental group showed a higher completely healed percentage of erosion, a greater reduction of erosion size and pain level. However, no significant difference was observed in the recurrence rate. No participants had any severe adverse reactions. In conclusion, an improvement was observed in patients with plaque control, and future studies with larger sample sizes are needed to reinforce the external validity of this study. Full article

(This article belongs to the Special Issue Oral Cancer and Oral Potentially Malignant Disorders: Evidence and Advances)

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Graphical abstract

17 pages, 679 KiB

Open AccessArticle

A Retrospective Cohort Study of Oral Leukoplakia in Female Patients—Analysis of Risk Factors Related to Treatment Outcomes

by Shih-Wei Yang, Yun-Shien Lee, Pei-Wen Wu, Liang-Che Chang and Cheng-Cheng Hwang

Int. J. Environ. Res. Public Health 2021, 18(16), 8319; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18168319 - 06 Aug 2021

Cited by 4 | Viewed by 3200

Abstract

Background: The aim of this study was to make a comparison of clinicopathological characteristics of oral leukoplakia between male and female patients following carbon dioxide laser excision for oral leukoplakia and analyze the factors associated with the treatment outcomes in female patients. Methods: Medical records of patients with oral leukoplakia receiving laser surgery from 2002 to 2020 were retrospectively reviewed and analyzed statistically. Results: A total of 485 patients were enrolled, including 412 male (84.95%) and 73 female (15.05%). Regarding the locations, the predilection site of oral leukoplakia in male patients was buccal mucosa (p = 0.0001) and that for women patients was tongue (p = 0.033). The differences of recurrence and malignant transformation between both sexes were not significant (p > 0.05). Among female patients, area of oral leukoplakia was the risk factor related to recurrence (p < 0.05). Clinical morphology and postoperative recurrence were the risk factors related to malignant transformation (p < 0.05). Conclusions: In comparison with male patients, there was no significant difference of the postoperative recurrence and malignant transformation of oral leukoplakia in female patients. Among the female patients, clinicians should pay more attention to large-sized and non-homogeneous leukoplakia, and postoperative recurrent lesions. Full article

(This article belongs to the Special Issue Oral Cancer and Oral Potentially Malignant Disorders: Evidence and Advances)

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Review

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21 pages, 1878 KiB

Open AccessReview

Laser Therapy for the Treatment of Actinic Cheilitis: A Systematic Review

by Angela Ayen-Rodriguez, Maria Jose Naranjo-Diaz and Ricardo Ruiz-Villaverde

Int. J. Environ. Res. Public Health 2022, 19(8), 4593; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph19084593 - 11 Apr 2022

Cited by 2 | Viewed by 3747

Abstract

Actinic cheilitis (AC) is a chronic inflammation of the lip considered an oral, potentially malignant disorder associated with an increased risk of lip squamous cell carcinoma (SCC) development. Controversies surrounding current therapeutic modalities of AC are under debate, and the implications of laser treatment have not been specifically investigated through a systematic review design. The present study aims to evaluate the degree of evidence of laser for the treatment of AC in terms of efficacy and safety. We searched for primary-level studies published before January 2022 through MEDLINE/PubMed, Embase, Web of Science, Scopus and CENTRAL, with no limitation in publication language or date. We evaluated the methodological quality and risk of bias of the studies included using the updated Cochrane Collaboration’s tool for assessing risk of bias (RoB-2). Twenty studies (512 patients) met our eligibility criteria. Laser therapy showed a complete clearance of AC in 92.5% patients, with a maximum recurrence rate of 21.43%, and a very low frequency of malignant transformation to SCC (detected in only 3/20 studies analyzed). In addition, cosmetic outcomes and patient satisfaction were described as excellent. In conclusion, our findings indicate that laser therapy is a high efficacy approach to AC. Full article

(This article belongs to the Special Issue Oral Cancer and Oral Potentially Malignant Disorders: Evidence and Advances)

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Figure 1

15 pages, 3048 KiB

Open AccessReview

Substance P and Neurokinin 1 Receptor in Chronic Inflammation and Cancer of the Head and Neck: A Review of the Literature

by Francisco Esteban, Pablo Ramos-García, Miguel Muñoz and Miguel Ángel González-Moles

Int. J. Environ. Res. Public Health 2022, 19(1), 375; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph19010375 - 30 Dec 2021

Cited by 12 | Viewed by 2529

Abstract

Head and neck cancer is a growing worldwide public health problem, accounting for approximately 1,500,000 new cases and 500,000 deaths annually. Substance P (SP) is a peptide of the tachykinin family, which has roles related to a large number of physiological mechanisms in humans. The implications of SP in carcinogenesis have recently been reported through the stimulation of the neurokinin 1 receptor (NK1R), or directly, through the effects derived from the constitutive activation of NK1R. Consequently, SP/NK1R seems to play relevant roles in cancer, upregulating cell proliferation, cell migration and chronic inflammation, among other oncogenic actions. Furthermore, there is growing evidence pointing to a central role for SP in tumour progression, singularly so in laryngeal and oral squamous cell carcinomas. The current narrative review of the literature focuses on the relationship between the SP/NK1R system and chronic inflammation and cancer in the head-and-neck region. We described a role for SP/NK1R in the transition from chronic inflammation of the head and neck mucosa, to preneoplastic and neoplastic transformation and progression. Full article

(This article belongs to the Special Issue Oral Cancer and Oral Potentially Malignant Disorders: Evidence and Advances)

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