Special Issue "Polycystic Ovary Syndrome (PCOS)"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Women's Health".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Dr. Michał Kunicki
E-Mail Website
Guest Editor
1. INVICTA Fertility and Reproductive Center, Warsaw, Poland
2. Department of Gynecological Endocrinology, Medical University of Warsaw, Warsaw, Poland
Interests: obstetric gynaecology; endocrinology; reproductive medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polycystic ovary syndrome (PCOS) is the most common and complex endocrinopathy worldwide, with a prevalence of 6–10%. The occurrence of PCOS is associated with hyperandrogenemia and/or hirsutism, ovulatory dysfunction, infertility, and many metabolic abnormalities. The latter includes insulin resistance, impaired glucose tolerance, diabetes mellitus, obesity, metabolic syndrome, hypertension, and dyslipidemia. Additionally, it has been reported that the prevalence of non-alcoholic fatty liver disease (NAFLD) is increased in women with PCOS.

 PCOS can also worsened quality of life, with some negative psychological aspects like depression; increased anxiety, mood, and sleeping disorders; and impaired quality of life (QoL). It is established that  therapy should focus on the aforementioned aspects in both the short and long term.

PCOS is also associated with adverse pregnancy outcomes, including gestational diabetes, preterm birth, and increased risk of preeclampsia. The pathophysiology of that disease is not totally elucidated, and hormonal, genetic, and environmental factors play a role.

Taking into account  that the PCOS has a great impact on women’s health, I would like to encourage submissions to our Special Issue that cover many aspects of that disease, including genetic, metabolic, reproductive, and especially environmental. We would gratefully accept the submission of both original and review studies. 

Dr. Michał Kunicki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • polycystic ovary syndrome
  • insulin resistance
  • obesity
  • infertility
  • treatment
  • assisted reproductive techniques
  • pregnancy outcomes
  • environment
  • toxins
  • quality of life

Published Papers (1 paper)

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Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study
Int. J. Environ. Res. Public Health 2021, 18(21), 11274; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph182111274 - 27 Oct 2021
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Metabolic and hormonal outcomes of polycystic ovary syndrome (PCOS) have implications on telomere biology and physical activity may prevent telomere erosion. We sought to observe the effects of continuous (CAT) and intermittent (IAT) aerobic training on telomere length, inflammatory biomarkers, and its correlation [...] Read more.
Metabolic and hormonal outcomes of polycystic ovary syndrome (PCOS) have implications on telomere biology and physical activity may prevent telomere erosion. We sought to observe the effects of continuous (CAT) and intermittent (IAT) aerobic training on telomere length, inflammatory biomarkers, and its correlation with metabolic, hormonal, and anthropometric parameters of PCOS. This randomized controlled clinical trial study included 87 PCOS randomly stratified according to body mass index (BMI) in CAT (n = 28), IAT (n = 29) and non-training control group (CG, n = 30). The exercises were carried out on a treadmill, three times per week for 16 weeks. The participants’ anthropometric characteristics and biochemical and hormonal concentrations were measured before and after aerobic training or observation period, as the telomere length that was evaluated using quantitative real-time PCR. Four months of aerobic exercises (CAT or IAT) did not alter telomere length and inflammatory biomarkers in PCOS women. Obesity index as BMI and waist circumference (WC), and inflammatory biomarkers negatively affect telomeres. The hyper-andro-genism measured by testosterone levels was reduced after both exercises (CAT, p ≤ 0.001; IAT, p = 0.019). In particular, the CAT reduced WC (p = 0.045), hip circumference (p = 0.032), serum cholesterol (p ≤ 0.001), and low-density lipoprotein (p = 0.030). Whereas, the IAT decreased WC (p = 0.014), waist-to-hip ratio (p = 0.012), free androgen index (FAI) (p = 0.037). WC (p = 0.049) and body fat (p = 0.015) increased in the non-training group while total cholesterol was reduced (p = 0.010). Booth exercises reduced obesity indices and hyperandrogenism on PCOS women without changes in telomere length or inflammatory biomarkers. Full article
(This article belongs to the Special Issue Polycystic Ovary Syndrome (PCOS))
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