Epigenetic Controls for Gene Panels in Oncology

Dear Colleagues,

In 2012, the Nobel prize in medicine was awarded to research on induced pluripotent stem cells (iPSC), which is important for regenerative medicine. The two gene panels generated were OCT4, SOX2, KLF4, and MYC (OSKM), and OCT4, SOX2, LIN28, and NANOG (OSLN). The gene panels are also found in the testicular cancer subtype embryonal carcinoma and in cancer stem cells. Their expression is governed by epigenetic mechanisms. Thus, a new point of view is the role of gene panels in oncology, being essential between different types of cancers. Gene panels may explain the development of cancers better than single genes do. A well-known example are the Vogelstein panels for colorectal cancer. Panels of genes may create blocks of RNA that may serve as new therapeutic targets. Many sources may lead to the understanding of gene panels in oncology. Gene panels may be sets of oncogenes and tumor suppressor genes or may work synergistically with known mutations, oncogenes and tumor suppressor genes. Therefore, the coming issue of the International Journal of Molecular Sciences welcomes experimental and clinical studies in oncology that advance the knowledge of the role of gene panels and epigenetic regulation of gene expression.

Dr. Finn Edler von Eyben
Guest Editor

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