State-of-the-Art Molecular Oncology in Brazil 3.0

Dear Colleagues,

This Special Issue follows the publication of the third edition on the topic “State-of-the-Art Molecular Oncology in Brazil”.

https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms/special_issues/Mol_Oncol_BR

https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms/special_issues/JKE9Y113YO

Cancer is a broad term to describe a large number of diseases characterized by the transformation of normal to abnormal tumor cells with uncontrolled proliferative capacity as a result of mutations, epigenetic alterations, exposure to toxicants and environmental conditions, as well as others. Tumor cells exhibit several molecular, morphological, and functional alterations, giving them proliferative advantages, the ability to escape from the immune system and cell death, and invasiveness capacity. In this regard, many studies focused on the molecular aspects of cancer have been conducted worldwide, aiming to improve our current understanding of tumor cell functioning, to describe molecular mechanisms of therapeutic options, and to discover novel targets and drugs for cancer treatment.

This Special Issue aims to highlight recent advances in cancer research in Brazil, focused on the molecular aspects of cancer. It includes studies conducted to unveil the molecular alterations exhibited by tumor cells, the proposal of novel targets for cancer therapy, and the mechanisms of action of drugs and drug candidates (including off-target effects and drug repurposing).

Thus, in order to provide a comprehensive view of recent advances in cancer research in Brazil, we invite researchers to submit original research papers and high-quality comprehensive reviews in the cancer research field to this Special Issue. Potential topics include but are not limited to the following:

• Molecular aspects of tumorigenesis;
• Mechanisms of evasion of cell death (apoptosis, necroptosis, autophagy, and others);
• Ionic and metabolic alterations in cancer;
• Molecular aspects of cancer therapy (mechanisms of drugs and drug candidates and new targets);
• Drug resistance mechanisms in cancer therapy.

Dr. Tiago Rodrigues
Prof. Dr. Roger Chammas
Guest Editors

Manuscript Submission Information

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• apoptosis
• autophagy
• calcium
• cancer
• cell death
• chemotherapy
• metabolism
• mitochondria
• drug resistance
• oxidative stress