Steroid Metabolism in Human Health and Disease 3.0

Dear Colleagues,

Steroid hormones are necessary for life, from salt balance by mineralocorticoids, sugar balance by glucocorticoids, to the growth, reproductive, and sexual functions of sex steroids.

Steroid hormones are synthesized from cholesterol, starting from conversion, to pregnenolone, which is then converted to many different metabolites in a series of metabolic reactions.

Defects in the steroid metabolism cause a wide range of disorders, including the most common endocrine disorder in women, polycystic ovary syndrome. Therefore, control of steroid hormones production and signalling is an attractive target for the treatment of many metabolic disorders, including hormonal dependent cancers (targeting CYP17A1 and the androgen receptor in prostate cancer, and aromatase in breast cancer).

This Special Issue will focus on the molecular biology and biochemistry of steroid hormones in health and disease, and potential topics of interest may include, but are not limited, to the following:

1. Molecular, cellular, and structural biology of steroid hormone production, regulation, and signalling in humans.
2. Genetics and pathology of metabolic disorders caused by the changes in steroid metabolism, including the study of human mutations causing disordered steroidogenesis.
3. Novel genes and mechanisms regulating steroid biosynthesis.
4. Targeting of steroid hormone production, regulation, and signalling in metabolic disorders, including hormone-dependent cancers, by drugs and protein therapeutics.

Through this Special Issue, we aim to provide the latest work on the topic of steroid metabolism in human health and disease by experts in the field to a broad range of readership.

Prof. Dr. Amit V. Pandey
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• steroid biosynthesis
• steroidogenesis
• androgen
• estrogen
• hormone-dependent cancers
• metabolic disorders
• steroid metabolizing enzymes