Skin Diseases: From Molecular Mechanisms to Pathology

Dear Colleagues,

The skin is a tissue at the interface between the host and the environment. It is the first line of defense against chemicals and physical insults and pathogens. This barrier function is of critical importance, which became evident after injury, in several different types of dermatitis, and in ichthyoses diseases.

Human skin is the largest immune organ that, in addition to providing a strong barrier against external insults, is fundamental in a wide variety of inflammatory processes, including immunity against infections, tumor immunity, autoimmunity, and allergy, continuously exposed to pathogens and external stress. This because, once the barrier is impaired, the rapid but nonspecific innate immune response is recruited in defense, a process that relies on detection of both self and foreign “danger signals” as the initial alarm. Next, the slower, but specific adaptive immune response may be required for definitive clearance of a pathogen.

The number of genetic skin disorders with known genetic defects has increased during the last decade. Advances in molecular biology provide new insights into immune and genetic aspects of skin diseases.

In this Special Issue of IJMS, we will publish cutting-edge information regarding recent advances in the research of skin diseases from molecular viewpoints. We warmly welcome research and review articles concerning a variety of factors relating to skin diseases, including their genetic/epigenetic regulation, therapy, and prevention. In this Special Issue, we aim to present molecular advances in all fields of skin diseases, whether inflammatory, neoplastic, or infectious.

Dr. Alessandro Terrinoni
Guest Editor

Manuscript Submission Information

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• skin diseases
• immunology
• genetics