New Insights into Lipids and Immune Responses

Dear Colleagues, 

In recent years, the intricate relationship between lipids and immune responses has gained considerable attention in the field of immunology. Lipids, once regarded primarily as structural components and energy sources, are now recognized as crucial players in modulating immune cell function and inflammation. The exploration of lipid–immune interactions has uncovered a plethora of novel mechanisms and signalling pathways that contribute to immune regulation, such as immune responses contributing towards protective immunity against bacterial infection, and immune dysregulation contributing towards autoimmune disorders. Several studies have explored the influence of lipid availability and metabolism on immune cell fate and function, unveiling key metabolic checkpoints that dictate immune cell differentiation and effector responses. Furthermore, novel lipid–protein interactions and lipid-mediated modulation of immune receptor signalling have been characterised, providing valuable insights into the intricate mechanisms through which lipids regulate immune cell activation and function. By providing a comprehensive view of the latest advancements in lipid-mediated immune responses, this Special Issue aims to deepen our understanding of the complex lipid–immune system interactions and their implications for the development of innovative therapeutic approaches.

Dr. Adam Shahine
Guest Editor

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• immune system
• lipids
• antigen presentation
• T-cell responses
• bacterial infection
• autoimmunity
• inflammation