The Roles of RNA (Coding and Non-coding) in Human Disease

Dear Colleagues,

RNA plays a multifaceted role in human disease, influencing pathogenesis at various levels. Beyond its fundamental role in protein synthesis, RNA is being increasingly recognized for its regulatory functions, impacting gene expression and cellular processes. Coding RNA and non-coding RNA represent two broad categories of RNA molecules with distinct roles in cellular processes. Coding RNA directs protein synthesis, and disruptions in its functionality contribute to diseases like cancer and neurodegeneration. Non-coding RNA, including microRNAs and long non-coding RNAs, intricately modulate gene expression and are implicated in diverse pathologies. RNA’s utility as a biomarker for disease diagnosis and prognosis is expanding, given its differential expression profiles in various conditions. Moreover, understanding RNA’s functional nuances provides insights into disease mechanisms, offering potential therapeutic targets. Innovative RNA-based therapies, such as RNA interference and antisense oligonucleotides, hold promise for precision medicine by targeting specific disease-related RNA aberrations. Unraveling the complex interplay of coding and non-coding RNA in human diseases not only refines diagnostic approaches but also opens avenues for developing novel, targeted therapeutics. In this Special Issue, we welcome the submission of research articles and full reviews.

Dr. Lee Lee Wong
Guest Editor

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• coding RNA
• non-coding RNA
• biomarker
• functional role
• therapeutic targets