Immunity, Inflammation, and Injury in the Pathogenesis and Progression of Kidney Diseases—from Bench to Bedside

Dear Colleagues,

Innate immunity is connected to all aspects of renal pathophysiology—from proteinuria through inborn anomalies, glomerulopathies, hypertension, nephrolithiasis, until end-stage kidney disease. It could be both the culprit and the victim of kidney dysfunction. Immunocompetent cells, in line with complement system, guard proper defense through multilayer mechanisms, including PAMPs recognition, NETs formation, or activation of autophagy, apoptosis, and tissue repair. And yet, when regulatory mechanisms escape control, friends become foes, autoimmune reactions trigger destruction, acute incidents turn into chronic episodes, and progressive processes turn into irreversible damage. The direction of changes strongly depends on the balance between reparatory and destructive mechanisms, between acuteness and chronicity of pathological changes, creating the positive loopback between immune reactions, inflammatory background, and injury of the kidney.

So far, the profound knowledge of immune mechanisms underlying kidney diseases has not been translated into efficient prophylaxis and early diagnosis.

Therefore, the current challenge is how to profit from the molecular background in order to improve diagnostic procedures and invent novel therapeutic tools in order to solve multiple nephrological puzzles. Let this Special Issue become a platform of exchanging ideas between scientists dealing with micromolecular tasks and clinicians compelled to solve macromolecular clinical problems for the patients’ good.

Prof. Dr. Kinga Musiał
Prof. Dr. Katarzyna Taranta-Janusz
Guest Editors

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• systemic immune inflammation index
• neutrophil extracellular traps
• pathogen associated molecular patterns
• damage associated molecular patterns
• complement system
• stress proteins
• acute kidney injury
• tubular damage
• chronic kidney disease
• hypertension
• glomerulopathy