Recent Highlights of Isatin-Based Hybrids as Promising Pharmacological Agents

Dear Colleagues,

Isatin (indol-2,3-dione), an endogenous oxidized indole found in the brain, peripheral tissues, and biological body fluids of humans and animals, exhibits a wide range of biological and pharmacological activities. They are realized via interactions with numerous biological targets. The isatin moiety is often considered a scaffold for the design of biologically active agents and its modification may potentiate the effectiveness and selectivity of resultant analogs towards particular biological targets. Many isatin-based hybrids have been synthesized and tested as antioxidants, inhibitors of HIV reverse transcriptase, anticancer, neuroprotective, anti-fungal, anti-bacterial, and anti-diabetic agents. In this context, there is a clear need for the analysis of mechanisms of action, such as isatin-based hybrids. This Special Issue of the International Journal of Molecular Sciences will focus on the multidisciplinary analysis of mechanisms responsible for the manifestation of biomedical (biological and pharmacological) effects of isatin and its analogs at various levels of structural organization of biological objects with a particular emphasis on their potential medical significance. Authors are cordially invited to submit their latest original research and reviews of recent experimental data within the scope of this Special Issue, which will cover all biomedical aspects related to both biological activities and biomedical applications of isatin-based hybrids and analogs. 

Prof. Dr. Alexei Medvedev
Guest Editor

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• isatin
• isatin analogues
• molecular hybridization approach
• isatin-based hybrids
• molecular targets
• biological activity
• pharmacological activity
• cell cultures
• animal models
• anticancer/antiporliferative activity
• antioxidant activity
• neuroprotection
• dual inhibitors