Biomaterials and Tissue Regeneration in Craniofacial Defect Reconstruction

Dear Colleagues,

Craniofacial defects can arise from various causes, including congenital anomalies, trauma, tumor resection, and surgical interventions. Reconstruction in the craniofacial region presents unique challenges due to the complex anatomy and the need to restore both functional and aesthetic aspects. Successful craniofacial defect reconstruction often requires a multidisciplinary approach to ensure comprehensive evaluation and customized treatment planning to address individual patient needs. Biomaterials play a crucial role in craniofacial defect reconstruction, serving as scaffolds for tissue regeneration or as implants to restore structural integrity. Tissue engineering approaches involving stem cells, growth factors, and bioactive scaffolds hold promise for enhancing tissue regeneration and improving long-term outcomes. These constructs elicit a complex biological response upon implantation. Various tangled signaling mechanisms orchestrate cellular activities essential for tissue repair and regeneration. Different types of cells interact with biomaterials to influence the healing process. Surface properties, such as topography and chemistry, modulate cell adhesion, proliferation, and differentiation. Understanding these molecular mechanisms enables tailoring specific regenerative applications in craniofacial defect reconstruction.

In this Special Issue, we invite contributions that shed light on the molecular mechanisms involved in the successful reconstruction of craniofacial defects. We encourage researchers to submit manuscripts presenting original research findings, review papers, innovative methodologies, and conceptual advances in this field. We aim to investigate and deepen the understanding of the molecular features defining the perfect craniofacial reconstruction model.

Prof. Dr. Ana Caruntu
Prof. Dr. Horia Barbu
Guest Editors

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• biomaterials
• biocompatibility
• tissue engineering
• craniofacial defect
• oral rehabilitation
• scaffolds
• regenerative medicine
• angiogenesis
• stem cells