Molecular Insight into Approaches against Cystic Fibrosis Infections

Dear Colleagues,

Cystic fibrosis (CF) is a life-limiting autosomal recessive disorder caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). Patients with cystic fibrosis suffer from problems in the respiratory system, pancreas, intestine and other organs, mainly related to increased mucus viscosity due to abnormal chlorine excretion. Lung disease is the main cause of reduced life expectancy and death in patients with CF. Moreover, because various bacteria can colonize the thick mucus, these patients mostly present with complications caused by infections in the respiratory tract, which are often difficult to eradicate. Indeed, the main pathogens, which include among other Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia complex, non-tuberculous Mycobacteria are usually naturally resistant to the antibiotics used in the clinic due to several factors, thus difficult to eradicate. Consequently, novel drugs as well as the development of alternative strategies (i.e., nitric oxide, antimicrobial peptides, phage therapy, vaccines, etc.) are urgently needed.

In this context, this Special Issue aims to collect original research as well as review articles covering all molecular aspects of research in the field of infections in Cystic Fibrosis.

This Special Issue is supervised by Dr. Chiarelli Laurent and assisted by our Topical Advisory Panel Member Giovanni Stelitano (University of Pavia).

Dr. Chiarelli Laurent
Guest Editor

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• cystic fibrosis
• infections
• multi-drug resistant pathogens
• new drugs
• anti-virulence compounds
• phage therapy
• vaccines