Molecular and Neuromuscular Mechanisms in Skeletal Muscle Aging

Dear Colleagues,

It is known that in humans, skeletal muscles account for about 40% of the body weight and are essential for overall health. With increasing age, muscle function declines, causing reduced mobility, thus leading to reduced independence and an increase in morbidity and mortality in the elderly. This age-related decline in muscle function is known as sarcopenia. Sarcopenia is a multifactorial disease that is defined as a progressive loss of muscle mass, strength, and function. It has attracted great research efforts to clarify its underlying mechanisms and potential treatments.

When aiming to discover hallmarks of aging, looking at shared age- and disease-related changes in cellular and muscular pathways such as apoptosis, cell cycle regulation, calcium handling, myokines, and catabolism can be helpful.

The aim of this Special Issue is essentially to collect new discoveries and study approaches to aging processes, mainly at the molecular and neuromuscular levels. For this Special Issue, we invite researchers to provide original research articles and review articles regarding results in the field of the new frontiers that can contribute to the understanding of the aging muscle process.

Dr. Rosa Mancinelli
Guest Editor

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• aging
• sarcopenia
• neuromuscular junction
• molecular muscle modifications
• myokines