Signaling in GPCR Research

Dear Colleagues,

G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface receptors. GPCRs are involved in transmitting signals from the extracellular environment to the inside of the cell. When a ligand binds to a GPCR, it induces a conformational change in the receptor, activating it. This is followed by the activation of a GTP-binding protein (G-protein), which in turn activates or inhibits various intracellular signaling pathways, such as cyclic AMP (cAMP) or phosphoinositide (PI) signaling pathways. These pathways ultimately lead to a variety of cellular responses, including the activation of protein kinases and phosphorylation of key proteins leading to changes in gene expression, metabolism and cell growth. GPCRs are involved in numerous physiological and pathological processes and are therefore targeted by a number of drugs for therapeutic purposes. Therefore, GPCR signaling is now a hot topic in drug design.

Prof. Dr. Zvi Naor
Guest Editor

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• GPCR
• G protein
• signaling
• drug design
• cell surface receptors