Nanomaterials for Targeted Drug Delivery
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".
Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 328
Special Issue Editors
Interests: mechanistic studies for developing and testing novel delivery technologies to deliver biotechnologically derived molecules (e.g., peptide, protein, and gene); gene delivery to prevent and treat neurodegenerative disorders, using nanotechnology; delivery of anticancer drugs to the brain for the treatment of brain tumors using bi-ligand (transferrin and cell-penetrating peptides) tethered liposomes; synthesis and characterization of biomaterials for gene and protein delivery for the treatment of diabetes, osteoporosis, and neurodegenerative diseases; fatty acid/amino acid and cell-penetrating peptide-grafted chitosan-based nanomicelles for the delivery of pDNA encoding IL-4 and IL-10 for the prevention of type 1 diabetes; cationic nanomicelles for the delivery of DNA vaccines
Special Issues, Collections and Topics in MDPI journals
Interests: design, development, and characterization of polymeric nanocarrier-based formulations for targeted delivery of small molecule drugs; plasmid DNA, siRNA, proteins, and peptides to treat cancer and neurological disorders; stem cell-based therapies for regenerative medicine, immunotherapy, and tumor-targeted delivery of chemotherapeutics; pharmacokinetic, toxicokinetic, and metabolic profiling of small molecule drug candidates and biologics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
With their unique physicochemical properties and nanoscale effects, nanoparticles can modulate the basic properties and bioactivity of drugs. These features make them attractive tools for diverse biomedical applications, especially in the field of drug delivery. Over the decades, nanocarriers have been extensively investigated for improved pharmacokinetics and biodistribution, increased stability, reduced toxicities, controlled release, and site-specific delivery of therapeutics. However, the efficacy of nanocarrier-based drug delivery systems is dependent mainly on their controlled interactions with biomolecules. Therefore, nanoparticles have often been surface-functionalized with various ligands, not only to impart site-specificity and increase cell penetration but also to provide stealth properties and improve payload capacity. For example, the surface functionalization of nanoparticles has made remarkable advances in tumor-targeted delivery and drug delivery across the blood-brain barrier. This Special Issue will focus on recent progress in nanotechnology in the areas of basic and applied research, as well as clinical medicine. Topics of interest include but are not limited to cutting-edge research on the preparation of surface-functionalized nanoparticles and their in vitro and in vivo evaluation. Further, the interaction between nanoparticles and bio-interfaces will also be included.
Prof. Dr. Jagdish Singh
Dr. Buddhadev Layek
Guest Editors
Manuscript Submission Information
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Keywords
- drug delivery
- gene delivery
- nanoparticles
- targeted drug delivery
- surface-functionalized nanoparticles
- pharmacokinetics
- controlled release
