Biological Effects of Internally Deposited Radionuclides

Dear Colleagues,

Most radiation-effects research has focused on the effects of exposures to external radiation. However, it is doses received from internally deposited radionuclides that contribute most to the total effective dose received by members of the public. In this respect lung doses from internally deposited radon progeny are most important. Occupational and medical exposures have been/are also commonly dominated by intakes of radionuclides including radium, uranium, thorium, gallium, technetium, and tritium isotopes. Moreover, new targeted radiotherapy methods employ radionuclides—often attached to antibodies to deliver specific local doses. Epidemiological studies of the impact of exposures to internally deposited radionuclides have been augmented by toxicology studies using animals. Together, these provide a base for our ongoing understanding of the effects of internal emitters and for the development of adverse outcome pathways. This Special Issue will highlight the latest research on lower-dose and lower-dose-rate effects, and how these may modify metabolic processes to either inhibit or promote disease—including cancer. We invite research articles presenting novel results, reviews, and/or perspectives addressing knowledge in this area. We look forward to your valuable contributions.

Suitable topics include, but are not limited to:

• DNA damage and subsequent mutagenesis and carcinogenesis
• Radioadaptive responses and hormetic effects of radionuclides
• Radionuclide deposition patterns within tissues and organs as a determinant of health risk
• Molecular biomarkers of exposure and bioindicators of health risks
• Biological effects resulting in therapeutic benefits and risk
• Dose response and biological dosimetry
• Radionuclide-specific effects
• Results of epidemiology and life-span studies
• Molecular epidemiology
• Consolidation of the knowledge of molecular mechanisms within the concept of adverse outcome pathways (AOP).

Dr. Nicholas D. Priest
Dr. Dmitry Klokov
Guest Editors

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• internal irradiation
• radionuclides
• alpha-emitters
• beta-emitters
• low dose effects
• epidemiology
• toxicolgy
• biomarkers
• biodosimetry
• metabolism
• DNA damage
• mutagenesis