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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights in Translational Bioinformatics
edited by
submission deadline 14 Jun 2024 | 7 articles | Viewed by 10381
Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology
(This special issue belongs to the Section Molecular Informatics)
Molecular Advances in Enzyme Kinetics
edited by
submission deadline 14 Jun 2024 | 2 articles | Viewed by 3758
Keywords: biocatalysis; enzymes; enzyme and inhibitors screening; enzyme computational modelling; kinetic data analysis; documentation of enzymatic data
(This special issue belongs to the Section Biochemistry)
From Basic Science to Treatment Strategies: Personalized Cancer Therapy
edited by Atif Hussein
submission deadline 15 Jun 2024 | 8 articles | Viewed by 16249 | Submission Open
Keywords: targeted therapy; personalized medicine; immunotherapy; circulating tumor DNA; prognosis; genomic profiling; liquid biopsies
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances and Perspectives of Lung Disease
edited by
submission deadline 15 Jun 2024 | 8 articles | Viewed by 14011 | Submission Open
Keywords: lung disease; inflammation; regeneration; infection; drug discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Transcriptome Complexity in Cancer and Leukemia: Alternative Splicing and Beyond
edited by
submission deadline 15 Jun 2024 | 5 articles | Viewed by 7344 | Submission Open
Keywords: messenger RNA (mRNA); long non-coding RNA (lncRNA); circular RNA (circRNA); transcriptional regulation; transcriptomics; solid tumors; hematological malignancies; biomarkers; therapeutic targets; therapy resistance
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Pathophysiology of Cerebral Gliomas: Towards Development of New Treatments submission deadline 15 Jun 2024 | 5 articles | Viewed by 7194 | Submission Open
Keywords: gliomas pathophysiology; biomarkers; microenvironment; cancer stem cells; brain resident cells; omics approaches; preclinical models; targeted treatment; brain drug delivery
(This special issue belongs to the Section Molecular Neurobiology)
Genetic Variability and Molecular Evolution of SARS-CoV-2 submission deadline 15 Jun 2024 | 6 articles | Viewed by 6776 | Submission Open
Keywords: SARS-CoV-2 phylogenomics; genetics; molecular epidemiology
(This special issue belongs to the Section Biochemistry)
New Advances in Type 2 Diabetes and Its Complications
edited by
submission deadline 15 Jun 2024 | 3 articles | Viewed by 6637 | Submission Open
Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms and Therapies of Lung Cancer
edited by and Marek Kimmel
submission deadline 15 Jun 2024 | 4 articles | Viewed by 6504 | Submission Open
Keywords: lung cancer; molecular mechanisms; multiomic data; mathematical modeling; molecular therapies
(This special issue belongs to the Section Molecular Oncology)
Plant Defense-Related Genes and Their Networks
edited by
submission deadline 15 Jun 2024 | 4 articles | Viewed by 6329 | Submission Open
Keywords: defence-related gene; defence-responsive genes; disease resistance; plant-pathogen interaction; plant immunity; protein modification; transcriptional profiling
(This special issue belongs to the Section Molecular Genetics and Genomics)
Human Immunodeficiency Virus-1 Infection: Molecular and Cellular Immunity
edited by
submission deadline 15 Jun 2024 | 4 articles | Viewed by 6137 | Submission Open
Keywords: HIV; PLWH; innate immunity; adaptive immunity; HIV controllers; HIV reservoir; non-AIDS events
(This special issue belongs to the Section Molecular Immunology)
Molecular Probe: Recent Research and Future Challenges submission deadline 15 Jun 2024 | 4 articles | Viewed by 6036 | Submission Open
Keywords: molecular imaging; radiotracer; probes; nanoparticles; diagnosis
(This special issue belongs to the Section Biochemistry)
Current Research in Pharmacognosy: A Focus on Biological Activities
edited by , , Artur Figueirinha and
submission deadline 15 Jun 2024 | 3 articles | Viewed by 5484 | Submission Open
Keywords: phytochemical characterization; volatile biomolecules; polyphenols; anticancer; anti-inflammatory; antimicrobial; antioxidant; synergism; toxicity
(This special issue belongs to the Section Molecular Pharmacology)
Innovative Strategies in the Development of Antivirals and Vaccines submission deadline 15 Jun 2024 | 2 articles | Viewed by 4671 | Submission Open
Keywords:   antivirals;   vaccines;   viruses;   innate immunity;   adaptive immunity;   viral replication;   antibodies;   immunological memory;   B and T cells
(This special issue belongs to the Section Molecular Microbiology)
Advances in Tomato Breeding and Molecular Research
edited by Silvana Grandillo, and
submission deadline 15 Jun 2024 | 5 articles | Viewed by 4648 | Submission Open
Keywords: tomato; natural and induced variation; genetics; genomics; omics; molecular breeding; physiology and development; fruit quality; biochemistry and metabolism; biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Insights on the Role of Stem Cells in Tendon Tissue Engineering: From Basic Science to Translational Medicine submission deadline 15 Jun 2024 | 4 articles | Viewed by 4500 | Submission Open
Keywords: stem cells; tenogenic differentiation; 3D in vitro tendon models; immunomodulation; biomimetic scaffolds; in vivo tendon models; dynamic cultures
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Therapies for Glioblastoma submission deadline 15 Jun 2024 | 3 articles | Viewed by 4388 | Submission Open
Keywords: glioblastoma; drug repurposing; drug delivery; biomaterials; immunotherapy; immune checkpoint inhibitors; oncolytic virotherapy; CAR-T cells; dendritic cell vaccination; spherical nucleic acids; gene therapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Gut Microbiota and Intestinal Diseases submission deadline 15 Jun 2024 | 3 articles | Viewed by 3847 | Submission Open
Keywords: dysbiosis; homeostasis; intestinal disease; bioactive molecules; gut health
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research of Biomedical X-ray Fluorescence Imaging (XFI)
edited by Florian Grüner
submission deadline 15 Jun 2024 | 3 articles | Viewed by 3713 | Submission Open
Keywords: X-ray fluorescence imaging; biomedical imaging; pharmacokinetics; drug development; non-desctructing testing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Experimental and Clinical Aspects of Allergies and Autoimmunity submission deadline 15 Jun 2024 | 3 articles | Viewed by 3665 | Submission Open
Keywords: advanced diagnostics; extracellular vesicles; hypersensitivity; immune regulation; long noncoding RNA; miRNA; novel therapeutics; research models of allergy and autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Inflammatory Bowel Disease’s Journey: From Metabolism and Immunity to New Therapeutic Horizons
edited by and Daniela Pugliese
submission deadline 15 Jun 2024 | 4 articles | Viewed by 3298 | Submission Open
Keywords: intestinal barrier function; gut microbiota; inflammation; bacterial metabolites; immunological pathways; biomarkers and predictors; nutrients; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Approaches to Understand, Prevent and Eradicate Biofilms and Related Infections—a New Look from Natural Compounds to Nanotechnology
edited by
submission deadline 15 Jun 2024 | 2 articles | Viewed by 3104 | Submission Open
Keywords: biofilm; natural compounds; nanotechnology; antibiotic resistance; mechanism of compound; bacteria; fungi; public health
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Research on Skeletal Muscle Diseases submission deadline 15 Jun 2024 | 4 articles | Viewed by 2724 | Submission Open
Keywords: muscle contraction; calcium regulation; desease-causing mutations; cross-bridge cycling and kinetics; thin filament; ATPase activity; actin– myosin interaction; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biodegradable Polymer: Structure, Properties and Applications submission deadline 15 Jun 2024 | 3 articles | Viewed by 2597 | Submission Open
Keywords: biodegradable polymers; synthesis; structure; properties; applications
(This special issue belongs to the Section Materials Science)
Regulation Mechanism of Osteoblast/Osteoclast Differentiation submission deadline 15 Jun 2024 | 2 articles | Viewed by 2550 | Submission Open
Keywords: bioactive compound; bone formation; bone remodeling; bone diseases; cancer; osteoblast; osteoclast
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Carbohydrate Structures in Targeted Drug Delivery
edited by Rosana Ribić
submission deadline 15 Jun 2024 | 1 articles | Viewed by 2493 | Submission Open
Keywords: carbohydrates; targeted drug delivery; drug– target interactions; glycoconjugates; glyconanoparticles; lipid-based drug delivery systems
(This special issue belongs to the Section Molecular Pharmacology)
Assimilate Production and Allocation in Plants under Abiotic Stress 2.0
edited by , and
submission deadline 15 Jun 2024 | 3 articles | Viewed by 2410 | Submission Open
Keywords: plant response; plant metabolism; abiotic stresses; drought; heat; cold; salt; heavy metal; high-light; low-light
(This special issue belongs to the Section Molecular Plant Sciences)
State-of-the-Art Molecular Immunology in Chile, 2nd Edition submission deadline 15 Jun 2024 | 2 articles | Viewed by 2237 | Submission Open
Keywords: innate immunity; adaptive immunity; host– pathogen interactions; immunopathology; osteoimmunology; immunosenescence; immunotherapy; antibody; vaccines; Chile
(This special issue belongs to the Section Molecular Immunology)
Molecular Research on Reproductive Toxicology
edited by Chiara Maria Motta
submission deadline 15 Jun 2024 | 2 articles | Viewed by 2198 | Submission Open
Keywords: environmental contamination; aquatic organisms; psychotropic drugs; gametogenesis; development; teratogenesis; gene expression; behavioral effects; oxidative stress; epigenotoxic effects; detoxification; bioaccumulation
(This special issue belongs to the Section Molecular Toxicology)
Epilepsy Research and Antiepileptic Drugs 2.0
edited by
submission deadline 15 Jun 2024 | 2 articles | Viewed by 1972 | Submission Open
Keywords: refractory epilepsy; pharmacoresistant epilepsy; antiepileptic drug; seizure; molecular mechanisms; prognosis; pharmacogenomics
(This special issue belongs to the Section Molecular Pharmacology)
Gynecological Cancer: Targeted Therapeutics and Future Perspectives
edited by Angela Santoro
submission deadline 15 Jun 2024 | 1 articles | Viewed by 1938 | Submission Open
Keywords:   molecular background;   precision medicine;   histomolecular diagnosis;   targeted therapies;   clinical trials;   overall survival;   disease-free survival;   gynecological cancer;   whole genomic assay;   molecular biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Effect of Food-Derived Compounds on Brown Fat Cell Function
edited by
submission deadline 15 Jun 2024 | 1 articles | Viewed by 1617 | Submission Open
Keywords: brown adipocyte; beige adipocyte; nutrients; food-derived components; thermogenesis; energy homeostasis; inflammation; obesity; diabetes; insulin resistance; metabolic syndrome; adipokines; lipid and carbohydrate metabolism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Metabolic Insights into Neuroinflammation and Neurodegeneration
edited by and Marika Lanza
submission deadline 15 Jun 2024 | 1 articles | Viewed by 1525 | Submission Open
Keywords: Parkinson’ s disease; Alzheimer’ s disease; metabolism; inflammation; neurodegeneration; drug discovery; pharmacological therapy
(This special issue belongs to the Section Molecular Neurobiology)
Bio-Nanopesticides
edited by
submission deadline 15 Jun 2024 | 1 articles | Viewed by 1477 | Submission Open
Keywords: bio-nanopesticides; sustainable agriculture; pest control; plant protection; nanotechnology; eco-friendly solutions; environmental impact; toxicity
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Advances in Muscular Dystrophy
edited by Sonia Albini
submission deadline 15 Jun 2024 | 1 articles | Viewed by 1340 | Submission Open
Keywords: (Muscular Dystrophy) MD; muscle regeneration; epigenetic regulators; biotherapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Oral Biofilms
edited by José Antonio Poli De Figueiredo and Carlos Estrela
submission deadline 15 Jun 2024 | 1 articles | Viewed by 1302 | Submission Open
Keywords: biofilms; oral tissues; dental tissues; molecular basis; dentine; enamel; microorganisms; prevention; treatment
(This special issue belongs to the Section Molecular Microbiology)
Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment submission deadline 15 Jun 2024 | 1 articles | Viewed by 1296 | Submission Open
(This special issue belongs to the Section Molecular Oncology)
Perspective Research on Antimicrobial Activities of Metals and Metal-Based Compounds
edited by Christopher Rensing
submission deadline 15 Jun 2024 | 1 articles | Viewed by 1243 | Submission Open
Keywords: metal-based nanoparticles; antibiotics; nanomedicine; mechanism of antibacterial activity
(This special issue belongs to the Section Molecular Microbiology)
Stress-Related Disorders and Depression: From Molecular Basis to Therapy (2nd Edition) submission deadline 15 Jun 2024 | 1 articles | Viewed by 1194 | Submission Open
Keywords: psychobiology of stress; depression; posttraumatic stress disorder; anxiety disorders; animal models; biogenic monoamines; glucocorticoids; inflammation; antidepressant and anxiolytic drugs
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Antithrombin in Blood Disorders
edited by
submission deadline 15 Jun 2024 | 1 articles | Viewed by 951 | Submission Open
Keywords: antithrombin; antithrombin deficiency; thrombosis; haemophilia; laboratory tests; molecular genetics; anticoagulant therapy  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Macromolecules and Hydrogel Formulations: Synthesis, Characterization, Pharmacological Effects and Possible Environmental Applications 2.0
edited by
submission deadline 15 Jun 2024 | 1 articles | Viewed by 882 | Submission Open
Keywords: (cationic) antibacterial nanoparticles; (cationic) anticancer nanoparticles; water-soluble bioactive nanoparticles; cross-linked materials (resins); (cationic) solubilizing macromolecules; swelling polymers; hydrogels formulations; drug delivery systems; environmental application of resins; spectroscopic characterization; rheological experiments; swelling and porosity characteristics; water loss studies; kinetic mathematical models; multivariate analyses (PCA)
(This special issue belongs to the Section Macromolecules)
Advances in Developmental Neurotoxicology
edited by
submission deadline 15 Jun 2024 | 1 articles | Viewed by 795 | Submission Open
Keywords: developmental neurotoxicology; neurodevelopmental models; neurotoxicants; neurodevelopmental disorders
(This special issue belongs to the Section Molecular Toxicology)
Molecular Thermodynamics of Nanostructured Materials: Trends and Prospects
edited by Fernando J.A.L. Cruz and
submission deadline 15 Jun 2024 | Viewed by 750 | Submission Open
Keywords: nanomaterials; thermodynamics; applications; synthesis
(This special issue belongs to the Section Molecular Nanoscience)
Advanced Flame Retardant Polymeric Materials 2.0
edited by
submission deadline 15 Jun 2024 | 1 articles | Viewed by 641 | Submission Open
Keywords: flame retardants; flame retardancy; fire resistance; fire safety; bio-based flame retardants; flame-retardant coatings; hybrid materials; polymer composites; multi-functionality; fire behaviors; smoke suppression; toxicity reduction; flame-retardant mechanisms
(This special issue belongs to the Section Macromolecules)
Original Approaches and Advanced Techniques in Molecular Magnetism Research
edited by Sergey L. Veber
submission deadline 15 Jun 2024 | 1 articles | Viewed by 594 | Submission Open
Keywords: molecular magnetism; coordination chemistry; spin-crossover materials; single-molecule magnets; magnetocaloric/magnetoelectric materials; magnetic field effects; spectroscopy; large-scale facilities; extreme conditions; computational approaches
(This special issue belongs to the Section Materials Science)
Natural Compounds in Cancer Therapy and Prevention 2.0 submission deadline 15 Jun 2024 | 1 articles | Viewed by 583 | Submission Open
Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs
(This special issue belongs to the Section Molecular Pharmacology)
Tumor Microenvironment in Cancer Cell Metastasis
edited by
submission deadline 15 Jun 2024 | Viewed by 375 | Submission Open
Keywords: tumour microenvironment; extracellular matrix; actin cytoskeleton; cancer cell metastasis
(This special issue belongs to the Section Molecular Oncology)
Modification and Functionalization of Polymers, Biopolymers, and Additives for Packaging Materials
edited by and Agnieszka Piegat
submission deadline 15 Jun 2024 | Viewed by 254 | Submission Open
Keywords: active packaging; biopolymers; bioactive additives; sustainable packaging; nanomaterials; antimicrobial packaging; antioxidant packaging; bio-based materials; functionalized packaging materials; characteristics of improved packaging performance
(This special issue belongs to the Section Materials Science)
Plant Bioactive Substances and Potential Applications submission deadline 15 Jun 2024 | Viewed by 250 | Submission Open
Keywords: bioactive compounds; chemical composition; natural-based extracts; biological activity; antimicrobial activity; antioxidant effect
(This special issue belongs to the Section Molecular Pharmacology)
Gene Transfer in Brain Disorders
edited by , Lluís Samaranch and Anne-Marie Duchemin
submission deadline 15 Jun 2024 | Viewed by 245 | Submission Open
Keywords: intellectual disability; neurodegenerative disorders; psychiatric diseases; gene transfer; AAV
(This special issue belongs to the Section Molecular Neurobiology)
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