Dear Colleagues,

Spinal tumors range from relatively rare primary tumors to the increasingly common metastatic disease of the spine. Although primary tumors of the spine are rare (<10% of spinal tumors), the number of patients with metastatic disease to the spine is substantial. Spinal metastases will be found in approximately 20% of all patients diagnosed with cancer (and in ≈70% of those with metastatic disease). The workup of the new spinal lesion can be challenging, and improper workup/treatment can lead to poor outcomes. By contrast, metastatic disease of the spine is relatively common, but multidisciplinary management is relevant for this pathology.

This Special Issue aims to provide an overview of current treatments for spinal tumors, both primary and metastatic, concerning surgery, radiotherapy, and systemic therapy, with a particular focus on innovative therapeutic pathways and multidisciplinary approaches.

Original research articles are especially requested, though a limited number of reviews can be accepted.

Dr. Riccardo Ghermandi
Dr. Cristiana Griffoni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• primary spinal tumors
• metastatic spinal disease
• surgery
• radiotherapy
• systemic therapy