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Recent Research and Progress of Biomaterials and Biodegradable Alloys for Medical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 November 2023) | Viewed by 1857

Special Issue Editors


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Guest Editor
Faculty of Mechanical Engineering, ”Gheorghe Asachi” Technical University of Iasi, Bd. Dimitrie Mangeron, nr. 67, 700050 Iaşi, România
Interests: biomaterials; coatings; microstructure
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The interest in biodegradable biomaterials and biocompatible alloys has increased steadily during the past decade. Designing biodegradable biomaterials and alloys requires mechanical properties that are proportional to their breakdown rate and biocompatibility with the biological system of the host. Conventional non-degradable metallic biomaterials, such as Stainless steels (SS), cobalt–chromium (Co–Cr) alloys and some of its alloys are commonly utilized as permanent or temporary implants to restore function by supporting hard tissues. However, these materials contain a variety of alloying elements, including aluminum (Al), vanadium (V), chromium (Cr), and nickel (Ni), which negatively impact their biocompatibility for tissue-engineering applications. This is caused by the fact that expressed in vitro cannot be maintained in harsh in vivo conditions. The next generation of biodegradable materials will contain multiple functions, with a high-end design that will require in-depth knowledge of the interaction between host tissues and bones, causing minimal adverse reactions. This Special Issue on “Recent Research and Progress of Biomaterials and Biodegradable Alloys for Medical Applications” aims to publish some of the best research and reviews performed in the area of metallic biomaterials applications and will cover several topics, but not limited to, such: 

  • Biodegradable metallic biomaterials
  • New metallic alloys as biomaterials
  • Design of metallic implants and prostheses;
  • Metal/tissue interfaces;
  • Osseointegration
  • Additive manufacturing of metallic biomaterials
  • Toxicological effects of biomaterials
  • Novel coatings for improving the performance of metals (i.e., wear, hardness, and corrosion resistance).

Dr. Bogdan Istrate
Prof. Dr. Corneliu Munteanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biodegradable alloys
  • biocompatible alloys
  • microstructural analysis
  • mechanical properties
  • corrosion resistance
  • in vitro & in vivo analysis

Published Papers (1 paper)

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Research

19 pages, 5672 KiB  
Article
A Novel PLLA/MgF2 Coating on Mg Alloy by Ultrasonic Atomization Spraying for Controlling Degradation and Improving Biocompatibility
by Wenpeng Peng, Yizhe Chen, Hongde Fan, Shanshan Chen, Hui Wang and Xiang Song
Materials 2023, 16(2), 682; https://0-doi-org.brum.beds.ac.uk/10.3390/ma16020682 - 10 Jan 2023
Cited by 4 | Viewed by 1525
Abstract
Problems of rapid degradation and poor biocompatibility (endothelialization and hemocompatibility) limit magnesium (Mg) alloy’s further applications in vascular stents. To solve these problems, a novel composite coating was designed on Mg alloy via a two-step method. First, a Mg alloy sample was immersed [...] Read more.
Problems of rapid degradation and poor biocompatibility (endothelialization and hemocompatibility) limit magnesium (Mg) alloy’s further applications in vascular stents. To solve these problems, a novel composite coating was designed on Mg alloy via a two-step method. First, a Mg alloy sample was immersed in hydrofluoric acid. Then, a poly-l-lactic acid (PLLA) coating was made by ultrasonic atomization spraying with 5 and 10 layers (referred to as PLLA(5)-HF-Mg and PLLA(10)-HF-Mg). Characterizations were analyzed from the microstructure, element distribution, and wettability. The degradation behavior was tested with an electrochemical test and immersion test. Endothelialization was investigated using human umbilical vein endothelial cells (HUVECs). Hemocompatibility was examined with a platelet adhesion test. The results showed that the PLLA coating could not only cover the surface, but also could permeate through and cover the holes on the MgF2 layer, mechanically locked with the substrate. Thus, the composite coating had higher corrosion resistance. The PLLA/MgF2 coating, especially on PLLA(10)-HF-Mg, enhanced HUVECs’ viability and growth. While incubated with platelets, the PLLA/MgF2 coating, especially on PLLA(10)-HF-Mg, had the lowest platelet adhesion number and activity. Taken together, the novel PLLA/MgF2 coating controls Mg alloy’s degradation by spraying different layers of PLLA, resulting in better endothelialization and hemocompatibility, providing a promising candidate for cardiovascular stents. Full article
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