Therapeutic Effects of Natural Products and Their Clinical Research

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 5 May 2024 | Viewed by 2184

Special Issue Editor


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Guest Editor
School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, QLD 4072, Australia
Interests: bioactive natural products; biochemical response to supplements; inflammation, signalling pathways; liver and kidney disease; exercise; absorption/bioavailability; exercise recovery; gastrointestinal health; intestinal permeability

Special Issue Information

Dear Colleagues,

Natural products, typically derived from plants, animals, and microorganisms, have long been recognized for their therapeutic potential. Natural compounds play a significant role in traditional medicine and are the basis of modern pharmaceuticals. Natural products are a valuable source of novel drug candidates, with numerous active compounds isolated and synthesized for various medical applications. Natural products also contribute to complementary and alternative medicine, as many individuals turn to herbal remedies for health and well-being. In recent years, clinical research has delved into the mechanisms of action of natural products, their safety, and efficacy. The therapeutic effects of natural products continue to offer promising avenues for improving healthcare and well-being.

The scope for natural products in clinical research is vast and continues to expand as our understanding of these compounds increases. Continued research, innovation, and collaboration between scientists and health professionals will further expand our understanding and application of these compounds in enhancing human health. This Special Issue aims to explore a wide range of natural products covering their potential benefits in human health through to their applied clinical effects.

Dr. David Briskey
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • therapeutic effects
  • natural products
  • clinical research
  • biochemical response to supplements
  • inflammation
  • signalling pathways
  • absorption
  • bioavailability
  • exercise
  • gastrointestinal health
  • intestinal permeability

Published Papers (1 paper)

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Research

10 pages, 753 KiB  
Article
Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants—A Double-Blind Randomised Controlled Study
by David Briskey, Rachael Skinner, Chelsie Smith and Amanda Rao
Pharmaceuticals 2024, 17(2), 145; https://0-doi-org.brum.beds.ac.uk/10.3390/ph17020145 - 23 Jan 2024
Viewed by 1831
Abstract
Migraines are a common neurological disorder that generally affects young to middle-aged adults and females more than males. Various treatment options are available; however, these can cause undesirable side effects. Therefore, alternative treatments with minimal side effects are still being investigated. Palmitoylethanolamide (PEA) [...] Read more.
Migraines are a common neurological disorder that generally affects young to middle-aged adults and females more than males. Various treatment options are available; however, these can cause undesirable side effects. Therefore, alternative treatments with minimal side effects are still being investigated. Palmitoylethanolamide (PEA) is a signalling lipid known to have anti-inflammatory and analgesic properties. Previous prophylactic research has reported PEA supplementation to decrease pain associated with migraines. Upon commencement of migraine symptoms, participants were supplemented with either 600 mg of PEA (Levagen+) or a placebo (maltodextrin). Once a dose was taken, participants recorded a visual analogue scale (VAS) for pain every 30 min for 4 h or until the migraine resolved. If the migraine had not resolved 2 h post-dose, participants were instructed to take a second dose. Levagen+ supplementation resolved more headaches after 2- and 8 h, had a lower VAS for pain score at 1.5 and 4 h, and reduced rescue medication use significantly more than a placebo. No adverse events were reported in either group. Overall, PEA was safe and effective in reducing migraine pain, duration, and medication use in an otherwise healthy adult population. Full article
(This article belongs to the Special Issue Therapeutic Effects of Natural Products and Their Clinical Research)
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