Plant-Derived Natural Compounds as Bioactive Molecules with Beneficial Effects on Human Health

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 968

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Guest Editor
Department of Galenic Pharmacy and Food Technology, Universitad Complutense de Madrid, Madrid, Spain
Interests: bioactive compound extraction; metabolic syndrome; bioactive polysaccharides; phenolic compounds; biological rhythms; mushrooms
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Special Issue Information

Dear Colleagues,

A strong correlation between natural compounds and health status has been assumed by modern populations. Moreover, the use of non-synthetic drugs can, in some cases, avoid certain disadvantages linked to conventional pharmaceuticals, such as adverse reactions or side effects and lack of specificity. Accordingly, research on vegetal compounds (e.g., peptides, phenolic compounds, lipids, polysaccharides/fibers, etc.) has exponentially increased over the last few decades. These investigations must cover raw materials selection (including by-product revalorization), extraction, analytical and biochemical techniques (following, to the greatest extent possible, the principles of sustainability and green chemistry), and biological activity tests that include in vitro and animal models but also require validation through clinical trials. Numerous plant-based nutraceuticals and drugs have been designed and evaluated, encouraging further investigation to finally integrate these products with conventional medicaments and thus obtain healthy alternatives. Therefore, the aim of this Special Issue is to investigate the latest findings and insights related to the study of vegetal bioactives, plant nutraceuticals, and drugs (including extraction and biochemical and biological activity analyses); identify current limitations; and elucidate future perspectives.

Dr. Diego Morales
Guest Editor

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Keywords

  • plant bioactives
  • bioactive compounds
  • gut microbiome
  • immune-modulatory
  • antioxidant
  • hypocholesterolemic
  • antihypertensive
  • clinical trials

Published Papers (1 paper)

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Research

15 pages, 4519 KiB  
Article
In Vivo Anti-Inflammatory and Antinociceptive Activities of Black Elder (Sambucus nigra L.) Fruit and Flower Extracts
by Daniela Seymenska, Desislava Teneva, Irina Nikolova, Niko Benbassat and Petko Denev
Pharmaceuticals 2024, 17(4), 409; https://0-doi-org.brum.beds.ac.uk/10.3390/ph17040409 - 23 Mar 2024
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Abstract
Sambucus nigra L. (S. nigra, SN) or black elder is a traditional medicinal plant widely used worldwide for therapeutic and dietary purposes. The aim of the current study was to investigate the anti-inflammatory and antinociceptive activities of black elder fruit and [...] Read more.
Sambucus nigra L. (S. nigra, SN) or black elder is a traditional medicinal plant widely used worldwide for therapeutic and dietary purposes. The aim of the current study was to investigate the anti-inflammatory and antinociceptive activities of black elder fruit and flower extracts (SNFrE and SNFlE, respectively). The primary polyphenol constituents in the flower extract were flavonoids and phenolic acids, while anthocyanins were the main components in the fruit extract. SNFrE revealed pronounced and dose-dependent in vivo anti-inflammatory activity assessed by the cotton pellet-induced granuloma test. Doses of 10, 20, and 50 mg/kg BW of SNFrE reduced the weight of induced granuloma in rats by 20.3%, 20.5%, and 28.4%, respectively. At the highest dose (50 mg/kg BW), SNFrE had significant (p < 0.01) anti-inflammatory activity comparable to that of diclofenac, the reference compound used (10 mg/kg BW). In addition, the in vivo antinociceptive activity of the extracts in mice was estimated using the acetic-acid-induced writhing test. Both extracts at doses of 50 mg/kg BW inhibited the abdominal contractions induced by the acetic acid significantly comparing to the control group (p < 0.01). Our findings indicate that black elder extracts and particularly SNFrE possess anti-inflammatory and antinociceptive activities, providing experimental evidence for the use of S. nigra in traditional medicine. Full article
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