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Pharmaceuticals
Special Issues
Superoxide Dismutase Activity in Different Health Conditions
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Superoxide Dismutase Activity in Different Health Conditions

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: closed (31 October 2021)

Special Issue Editors

Dr. Marta Kepinska

E-Mail Website
Guest Editor
Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland
Interests: oxidative stress; protein–protein interactions; metallothionein, nanoparticles; toxicology
Dr. Anna Prescha

E-Mail Website
Guest Editor
Department of Food Science and Dietetics, Wroclaw Medical University, 50-556 Wrocław, Poland
Interests: xenobiotics; oxidative stress; dietary factors in health and disease; bioactive lipid compounds; nutritional assessment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Superoxide dismutase (SOD) is one of the most important enzymatic antioxidants, having the ability to neutralize superoxide due to catalytic disproportionation. SOD enzymes control the levels of reactive oxygen species, limiting their potential toxicity and regulating various aspects of cell life. The impact of SOD gene polymorphisms and/or alterations in SOD expression and activity have been observed in different pathological states including familial amyotrophic lateral sclerosis, inflammatory diseases, cystic fibrosis, chronic obstructive pulmonary disease, ischemia, as well as obesity and its metabolic and cardiovascular complications, but also in degenerative processes related to aging.

The protective role of SOD isoforms (SOD1, SOD2, SOD3) and their linkage to the most prevalent diseases of modern society is a topic of increasing interest. The regulation of SOD concentration and/or activity may be a way of treating the above-mentioned diseases. Furthermore, SOD conjugates or its mimics can overcome the limitations of the free enzyme and can be used as a pharmaceutical in the treatment of different diseases.

The Special Issue “Superoxide Dismutase Activity in Different Health Conditions” will cover research topics and current review articles in this field.

Dr. Marta Kepinska
Dr. Anna Prescha
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Superoxide dismutase (SOD)
  • Oxidative stress
  • Antioxidant defense
  • Enzyme activity
  • Gene polymorphism
  • SOD mimesis
  • Cu,Zn-SOD
  • Mn-SOD

Published Papers (1 paper)

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Research

18 pages, 1565 KiB  
Article
Serum Total SOD Activity and SOD1/2 Concentrations in Predicting All-Cause Mortality in Lung Cancer Patients
by Katarzyna Beata Skórska, Sylwia Płaczkowska, Anna Prescha, Irena Porębska, Monika Kosacka, Konrad Pawełczyk and Katarzyna Zabłocka-Słowińska
Pharmaceuticals 2021, 14(11), 1067; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14111067 - 21 Oct 2021
Cited by 12 | Viewed by 2408
Abstract
Redox status disturbances are known during carcinogenesis and may have influence on patients’ survival. However, the prediction of mortality in lung cancer patients based on serum total SOD activity, and concentrations of its isoforms, has not been studied to date. This prospective cohort [...] Read more.
Redox status disturbances are known during carcinogenesis and may have influence on patients’ survival. However, the prediction of mortality in lung cancer patients based on serum total SOD activity, and concentrations of its isoforms, has not been studied to date. This prospective cohort study has following aims: (1) to evaluate the disturbances in serum SOD activity and SOD1/2 concentrations; (2) to assess the implications of these alterations with regard to biochemical variables and clinical data, and (3) to investigate the association between serum SOD activity, SOD1/2 concentrations, and all-cause mortality in lung cancer patients. Serum total SOD activity and SOD1, SOD2, albumin, CRP, and ceruloplasmin concentrations were determined in lung cancer patients (n = 190) and control subjects (n = 52). Additionally, patients were characterized in terms of biochemical, clinical, and sociodemographic data. Multiple Cox regression models were used to estimate the association between all-cause death and SOD-related parameters. All-cause mortality in lung cancer was positively associated with serum SOD1 and SOD2 concentrations. Clinical stage III and IV disease was the strongest predictor. The utility of the evaluated parameters in predicting overall survival was demonstrated only for SOD1. Serum SOD1 and SOD2 concentrations were shown to positively affect all-cause mortality in lung cancer patients, but SOD1 seems to be a better predictor than SOD2. Full article
(This article belongs to the Special Issue Superoxide Dismutase Activity in Different Health Conditions)
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