Discovery, Metabolism and Potential Bio-Activities of Natural Products in Traditional Medicine 2024

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 1028

Special Issue Editors


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Guest Editor
School of Medicine, Kunming University, Kunming, 650208, China
Interests: isolation and identification of plant and microbial natural products
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Special Issue Information

Dear Colleagues,

Traditional medicine is a precious commodity accumulated by the struggle between human beings and nature. A large number of studies have found that natural products in traditional medicines contain active substances that treat diseases. Many of those natural products are being developed into clinical drugs or used as lead compounds for drug design and synthesis. With the development of modern separation technology, more and more trace natural products or metabolites have been discovered and identified. Moreover, it is well-known that the bioavailability and metabolic characteristics of natural products in vivo are an important basis for their biological activities. In addition, the exploration of the potential biological activities of those natural products is conducive to their further drug development and application. Therefore, this Special Issue is expected to collect original works or reviews on the latest advances and prospects of discovery, metabolism and potential bio-activities of natural products in traditional medicine. With this Special Issue, we hope to publish research results that will further promote people's understanding of the properties of the natural products isolated from traditional medicine and to contribute to the development of drugs based on those natural products.

Prof. Dr. Shengbao Cai
Prof. Dr. Jiangbo He
Guest Editors

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Keywords

  • traditional medicine
  • natural product
  • bioaccessibility and bioavailability
  • bioactivity evaluation
  • metabolism

Published Papers (1 paper)

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Research

22 pages, 11173 KiB  
Article
Exploring the Mechanisms of Traditional Chinese Herbal Therapy in Gastric Cancer: A Comprehensive Network Pharmacology Study of the Tiao-Yuan-Tong-Wei decoction
by Juan Chen, Jingdong Kang, Shouli Yuan, Peter O’Connell, Zizhu Zhang, Lina Wang, Junying Liu and Rongfeng Chen
Pharmaceuticals 2024, 17(4), 414; https://0-doi-org.brum.beds.ac.uk/10.3390/ph17040414 - 25 Mar 2024
Cited by 1 | Viewed by 687
Abstract
The use of herbal medicine as an adjuvant therapy in the management of gastric cancer has yielded encouraging outcomes, notably in enhancing overall survival rates and extending periods of disease remission. Additionally, herbal medicines have demonstrated potential anti-metastatic effects in gastric cancer. Despite [...] Read more.
The use of herbal medicine as an adjuvant therapy in the management of gastric cancer has yielded encouraging outcomes, notably in enhancing overall survival rates and extending periods of disease remission. Additionally, herbal medicines have demonstrated potential anti-metastatic effects in gastric cancer. Despite these promising findings, there remains a significant gap in our understanding regarding the precise pharmacological mechanisms, the identification of specific herbal compounds, and their safety and efficacy profiles in the context of gastric cancer therapy. In addressing this knowledge deficit, the present study proposes a comprehensive exploratory analysis of the Tiao-Yuan-Tong-Wei decoction (TYTW), utilizing an integrative approach combining system pharmacology and molecular docking techniques. This investigation aims to elucidate the pharmacological actions of TYTW in gastric pathologies. It is hypothesized that the therapeutic efficacy of TYTW in counteracting gastric diseases stems from its ability to modulate key signaling pathways, thereby influencing PIK3CA activity and exerting anti-inflammatory effects. This modulation is observed predominantly in pathways such as PI3K/AKT, MAPK, and those directly associated with gastric cancer. Furthermore, the study explores how TYTW’s metabolites (agrimoniin, baicalin, corosolic acid, and luteolin) interact with molecular targets like AKT1, CASP3, ESR1, IL6, PIK3CA, and PTGS2, and their subsequent impact on these critical pathways and biological processes. Therefore, this study represents preliminary research on the anticancer molecular mechanism of TYTW by performing network pharmacology and providing theoretical evidence for further experimental investigations. Full article
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