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Special Issue Editors

Prof. Dr. Renata Adami

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Guest Editor

1. Department of Physics “E. R. Caianiello”, University of Salerno, 84084 Fisciano, SA, Italy
2. NanoMates Center, University of Salerno, 84084 Fisciano, SA, Italy
Interests: chemical engineering; chemical processes; nanotechnology; nano- and micro-particles; microspheres; microcapsules; controlled release; extraction and fractionation; supercritical fluids; pharmaceutical; nutraceuticals; natural science; biomedical; chromatography; spectroscopy; scanning electron microscopy; laser technology

Prof. Dr. Teresa Casimiro

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LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829–516 Caparica, Portugal
Interests: supercritical fluid technology; synthesis and processing of polymers; green chemistry; molecularly imprinted polymers
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Dr. Clarinda Costa

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Guest Editor

SSPC Research Centre, Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland
Interests: nano(bio)pharmaceuticals; supercritical carbon dioxide-based techniques; nanocrystallization; nano and microparticles; microfluidics; oral and pulmonary drug administration

Special Issue Information

Dear Colleagues,

The 17 sustainable development goals (SDGs) from the 2030 Agenda for Sustainable Development, adopted by the UN Member States in 2015, express a plan of action for people, planet, and prosperity. Several of these goals highlight the promotion of well-being for all, reducing inequality within and among countries, promoting inclusive and sustainable industrialization, and fostering innovation. Dry powder formulations offer controlled drug release, reduced local and systemic toxicities, patient compliance, and storage stability by avoiding cold distribution and supply chains (known as one of the biggest challenges related to the current mRNA-based SARS-CoV-2019 vaccines), with increasing industrial implementation. Therefore, this Special Issue aims to highlight the most recent advances in novel dry powder formulations, delivery platforms, and controlled release systems of small molecule drugs, vaccines, and biopharmaceuticals. This Special Issue will also address green, continuous, and combined processes for particle engineering, from fundamental to application-based studies, and the challenges faced in industrial implementation. Given the relevance behind the research in this field, it is my pleasure to invite you to submit, in this Special Issue, your original research articles, reviews and together contribute to a sustainable and inclusive world.

Prof. Dr. Renata Adami
Prof. Dr. Teresa Casimiro
Dr. Clarinda Costa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

dry powder formulations
delivery platforms and controlled release systems
green chemistry and engineering
small molecule drugs, vaccines, and biopharmaceuticals
micro and nanoparticles
continuous manufacturing
particle engineering
industrial implementation

Published Papers (2 papers)

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Research

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23 pages, 7926 KiB

Open AccessArticle

The Processing Space of the Spray-Dried Mannitol-Leucine System for Pulmonary Drug Delivery

by Riley T. Schweizer, Mani Ordoubadi, Cody A. Prather, Reinhard Vehring and Kimberly B. Shepard

Pharmaceutics 2024, 16(3), 398; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics16030398 - 14 Mar 2024

Viewed by 1168

Abstract

Designing spray-dried particles for inhalation aims at specific physicochemical properties including a respirable aerodynamic diameter and adequate powder dispersibility. Leucine, an amphiphilic amino acid, has been shown to aid in optimizing bulk powder properties. Mannitol, a model crystalline active and common bulking agent, was co-sprayed with leucine at several excipient ratios, ethanol/water ratios, and spray dryer outlet temperatures in order to experimentally probe the underlying particle formation mechanisms in this binary crystalline system. During the droplet drying of two crystallizing components, the material that nucleates first will preferentially enrich the surface. It is desired to have a completely crystalline leucine shell to improve powder properties, however, mannitol competes with leucine for the surface depending on excipient concentration and manufacturing parameters. The resulting particles were studied initially and at a two-month timepoint via solid state characterization, visual analysis, and particle size analysis in order to detect changes in bulk powder properties. It was determined that, similar to systems where only leucine can crystallize, initial leucine saturation in the formulation dictates powder characteristics. Full article

(This article belongs to the Special Issue Novel Dry Powder Formulation and Delivery Systems)

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Review

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26 pages, 3141 KiB

Open AccessReview

Advances in Transdermal Drug Delivery Systems: A Bibliometric and Patent Analysis

by Aniello Cammarano, Stefania Dello Iacono, Caterina Meglio and Luigi Nicolais

Pharmaceutics 2023, 15(12), 2762; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics15122762 - 12 Dec 2023

Viewed by 1291

Abstract

Transdermal drug delivery systems have become an intriguing research topic in healthcare technology and one of the most frequently developed pharmaceutical products in the global market. In recent years, researchers and pharmaceutical companies have made significant progress in developing new solutions in the field. This study sheds light on current trends, collaboration patterns, research hotspots, and emerging frontiers of transdermal drug delivery. Herein, a bibliometric and patent analysis of data recovered from Scopus and The Lens databases, respectively, is reported over the last 20 years. From 2000 to 2022, the annual global publications increased from 131 in 2000 to 659 in 2022. Researchers in the United States, China, and India produced the highest number of publications. Likewise, most patent applications have been filed in the USA, China, and Europe. The recovered patents are 7275, grouped into 2997 patent families, of which 314 were granted. This study could support the work of decision-makers, scientific managers, or scientists to create new business opportunities or save money, time, and intellectual capital, thereby defining when a research or technology project should be a priority or not. Full article

(This article belongs to the Special Issue Novel Dry Powder Formulation and Delivery Systems)

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