Curcumin in Biomedical Applications, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1226

Special Issue Editors


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Guest Editor
Department of Animal Biotechnology, Jeju International Animal Research Center (JIA) and Sustainable Agriculture Research Institute (SARI), Jeju National University, Jeju 63243, Republic of Korea
Interests: bioavailability of poorly soluble drugs; nanotechnology; nanomedicine; biotechnology; pharmacology; veterinary medicine; animal science
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Subtropical Horticulture Research Institute, Jeju National University, Jeju 63243, Republic of Korea
Interests: nanomedicine; phytomedicine; genomics; proteomics; pharmacokinetics; characterization of nanoparticles; bioactive functional compounds; cell line culture; animal models

E-Mail Website
Guest Editor
Department of Animal Biotechnology, Jeju International Animal Research Center (JIA) and Sustainable Agriculture Research Institute (SARI), Jeju National University, Jeju 63243, Republic of Korea
Interests: nanomedicine; nanocarriers; pharmacology; toxicology; biotechnology; nanotechnology; animal nutrition; animal physiology; immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Curcumin, a hydrophobic and polyphenolic compound extracted from the perennial herb Curcuma longa, is used in various biomedical applications. Curcumin has antioxidant, antimicrobial, anti-inflammatory, and neuroprotective effects on human and animal health; it has several limitations, including poor water solubility and an unstable chemical structure, rapid metabolization but poor absorption in the body, as well as differing utilization and bioavailability depending on the species and sex of the organism. In this regard, curcumin in the form of a nanoparticle has been widely reported to enhance the bioavailability and solubility of lipophilic curcumin. In recent years, several studies have shown the beneficial effects of nanocurcumin over native curcumin in terms of quantity and efficacy. It is also important to know how effectively nanocurcumin can work in biological systems based on pharmacokinetic and pharmacodynamic tools. For this, different types of carrier vehicles, such as lipid nanoparticles and polymeric nanoparticles, can be used to increase the bioavailability of curcumin. The utilization of novel formulations of curcumin in medical and veterinary applications may improve the health status of humans as well as the sustainable production of farm animals. In addition, its use might help minimize the excessive use of antibiotics in biomedical applications.

This Special Issue intends to focus on research articles and review papers covering recent progress and achievements in curcumin research in both human and animal science.

Prof. Dr. Taesun Min
Dr. Adhimoolam Karthikeyan
Dr. Mohammad Moniruzzaman
Guest Editors

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Keywords

  • curcumin
  • biotechnology
  • pharmacology
  • nanospheres
  • nanocarriers
  • drug delivery
  • human
  • aquatic animal
  • terrestrial animal
  • in vitro study
  • in vivo study

Published Papers (1 paper)

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Research

15 pages, 2298 KiB  
Article
Neuroprotective Effect of Curcumin-Loaded RGD Peptide-PEGylated Nanoliposomes
by Amina Ben Mihoub, Kamil Elkhoury, Janske Nel, Samir Acherar, Emilie Velot, Catherine Malaplate, Michel Linder, Shahrzad Latifi, Cyril Kahn, Marion Huguet, Frances T. Yen and Elmira Arab-Tehrany
Pharmaceutics 2023, 15(12), 2665; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics15122665 - 24 Nov 2023
Cited by 1 | Viewed by 963
Abstract
Curcumin is known for its anti-inflammatory, neuroprotective, and antioxidant properties, but its use in biological applications is hindered by its sensitivity to light, oxygen, and temperature. Furthermore, due to its low water solubility, curcumin has a poor pharmacokinetic profile and bioavailability. In this [...] Read more.
Curcumin is known for its anti-inflammatory, neuroprotective, and antioxidant properties, but its use in biological applications is hindered by its sensitivity to light, oxygen, and temperature. Furthermore, due to its low water solubility, curcumin has a poor pharmacokinetic profile and bioavailability. In this study, we evaluated the potential application of curcumin as a neuroprotective agent encapsulated in RGD peptide-PEGylated nanoliposomes developed from salmon-derived lecithin. Salmon lecithin, rich in polyunsaturated fatty acids, was used to formulate empty or curcumin-loaded nanoliposomes. Transmission electron microscopy, dynamic light scattering, and nanoparticle tracking analysis characterizations indicated that the marine-derived peptide-PEGylated nanoliposomes were spherical in shape, nanometric in size, and with an overall negative charge. Cytotoxicity tests of curcumin-loaded nanoliposomes revealed an improved tolerance of neurons to curcumin as compared to free curcumin. Wild-type SH-SY5Y were treated for 24 h with curcumin-loaded nanoliposomes, followed by 24 h incubation with conditioned media of SH-SY5Y expressing the Swedish mutation of APP containing a high ratio of Aβ40/42 peptides. Our results revealed significantly lower Aβ-induced cell toxicity in cells pre-treated with RGD peptide-PEGylated curcumin-loaded nanoliposomes, as compared to controls. Thus, our data highlight the potential use of salmon lecithin-derived RGD peptide PEGylated nanoliposomes for the efficient drug delivery of curcumin as a neuroprotective agent. Full article
(This article belongs to the Special Issue Curcumin in Biomedical Applications, 2nd Edition)
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