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Pharmaceutics
Special Issues
New Nano-Systems for Imaging, Diagnostics, and Drug Delivery
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New Nano-Systems for Imaging, Diagnostics, and Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 609

Special Issue Editors

Dr. Iris Batalha

E-Mail Website
Guest Editor
Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
Interests: nanomedicine; infectious diseases; drug delivery; formulation; affinity; bioseparations
Special Issues, Collections and Topics in MDPI journals
Dr. Daniel Gonzalez-Carter

E-Mail Website
Guest Editor
Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
Interests: nanomedicine; drug delivery; blood-brain barrier; brain disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Lorena Ruiz-Pérez

E-Mail Website
Guest Editor
1. Department of Applied Physics, University of Barcelona, 08028 Barcelona, Spain
2. Molecular Bionics Lab, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
Interests: in situ TEM; misfolded proteins; protein aggregation and dynamics; mesoscale systems; polymer self-assembly; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue of the Pharmaceutics and Nanomaterials MDPI journals on the topic of “New Nano-Systems for Imaging, Diagnostics, and Drug Delivery”.

The advent of mRNA vaccines has demonstrated the potential of nanomaterial-based systems to have a beneficial clinical impact. However, many challenges remain in material design to optimize responsiveness, bioreactivity and scalability, as well as therapy encapsulation, tissue targeting and controlled release.

This Special Collection aims to highlight the latest developments and efforts in the field to translate nanomaterials into clinical practice. Original research articles and reviews are welcome. Research areas may include, but are not limited to, imaging, diagnostics and drug delivery materials applied to oncology, immunology or neuroscience.

We look forward to receiving your contributions.

You may choose our Joint Special Issue in Nanomaterials.

Dr. Iris Batalha
Dr. Daniel Gonzalez-Carter
Dr. Lorena Ruiz-Pérez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicine
  • drug delivery
  • imaging
  • diagnostics

Published Papers (1 paper)

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Research

14 pages, 4213 KiB  
Article
Modulating the Nature of Ionizable Lipids and Number of Layers in Hyaluronan-Decorated Lipid Nanoparticles for In Vitro Delivery of RNAi
by Victor Passos Gibson, Houda Tahiri, Claudia Gilbert, Chun Yang, Quoc Thang Phan, Xavier Banquy and Pierre Hardy
Pharmaceutics 2024, 16(4), 563; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics16040563 - 20 Apr 2024
Viewed by 434
Abstract
Lipid nanoparticles (LNPs) have established their position as nonviral vectors for gene therapy. Tremendous efforts have been made to modulate the properties of LNPs to unleash their full clinical potential. Among the strategies being pursued, the layer-by-layer (LbL) technique has gained considerable attention [...] Read more.
Lipid nanoparticles (LNPs) have established their position as nonviral vectors for gene therapy. Tremendous efforts have been made to modulate the properties of LNPs to unleash their full clinical potential. Among the strategies being pursued, the layer-by-layer (LbL) technique has gained considerable attention in the biomedical field. Illuminated by our previous work, here we investigate if the LbL approach could be used to modify the LNP cores formulated with three different ionizable lipids: DODMA, MC3, and DODAP. Additionally, we wondered if more than three layers could be loaded onto LNPs without disrupting their gene transfection ability. Taking advantage of physicochemical analysis, as well as uptake and gene silencing studies, we demonstrate the feasibility of modifying the surface of LNPs with the LbL assembly. Precisely, we successfully modified three different LNPs using the layer-by-layer strategy which abrogated luciferase activity in vitro. Additionally, we constructed a 5×-layered HA-LNP containing the MC3 ionizable lipid which outperformed the 3×-layered counterpart in transfecting miRNA-181-5p to the pediatric GBM cell line, as a proof-of-concept in vitro experiment. The method used herein has been proven reproducible, of easy modification to adapt to different ionizable lipid-containing LNPs, and holds great potential for the translation of RNA-based therapeutic strategies. Full article
(This article belongs to the Special Issue New Nano-Systems for Imaging, Diagnostics, and Drug Delivery)
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