Recent Advances in Biomedical Applications of Magnetic Nanomaterials

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 255

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Physics-Biophysics, Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Pasteur 6, 400349 Cluj-Napoca, Romania
Interests: magnetic nanoparticles; magnetic hyperthermia; plasmonic nanoparticles; vibrational spectroscopy; Surface Enhanced Raman Spectroscopy (SERS); liposomes
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Guest Editor
Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Kwei-San, Taoyuan 33302, Taiwan
Interests: target thrombolysis; nanomedicine; nano-biointerface; pharmacology; hemodynamics

Special Issue Information

Dear Colleagues,

Magnetic nanoparticles (MNPs) have emerged as promising candidates for a wide array of biomedical applications due to their unique responsiveness to external magnetic fields, which enables remote control and manipulation.

In recent years, extensive research efforts have been dedicated to exploring the applications of magnetic nanoparticles (MNPs) in biomedical fields, including their use as contrast agents in magnetic resonance imaging (MRI), or more recently using the magnetic particle imaging technique. Additionally, MNPs have shown promise in cancer therapy through magnetic hyperthermia, where they are subjected to radiofrequency magnetic fields to induce heating for therapeutic purposes. Moreover, the fabrication of hybrid nanostructures by combining MNPs with polymers, fluorophores, liposomes, and plasmonic or silica shells has opened up new possibilities for both diagnosing and treating medical conditions. These multifaceted nanomaterials offer the unique capability of remote control over their positioning and activation, positioning them as a highly investigated class of theranostic materials.

We aim for this Special Issue, titled "Recent Advances in Biomedical Applications of Magnetic Nanomaterials", to provide a platform for researchers to share their latest experimental and theoretical findings related to the development and application of magnetic nanomaterials in the medical field, where we welcome both reviews and research papers focused on distinct aspects of medical applications of MNPs.

Prof. Dr. Constantin Mihai Lucaciu
Prof. Dr. Yunn-Hwa Ma
Guest Editors

Manuscript Submission Information

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Keywords

  • magnetic hyperthermia
  • magnetoplasmonic nanoparticles
  • targeted drug delivery
  • magnetoliposomes
  • magnetic resonance imaging
  • magnetic particle imaging

Published Papers (1 paper)

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Research

15 pages, 1940 KiB  
Article
Targeted Thrombolysis with Magnetic Nanotherapeutics: A Translational Assessment
by Ming-Lu Lin, Siao-Yun Wu, Jyh-Ping Chen, Yi-Ching Lu, Shih-Ming Jung, Shiaw-Pyng Wey, Tony Wu and Yunn-Hwa Ma
Pharmaceutics 2024, 16(5), 596; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics16050596 (registering DOI) - 27 Apr 2024
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Abstract
Plasminogen activators, such as recombinant tissue-type plasminogen activators (rtPAs), while effective in treating thromboembolic diseases, often induce hemorrhagic complications due to non-specific enzyme activities in the systemic circulation. This study evaluated the targeting efficiency, efficacy, biodistribution, and potential toxicity of a rtPA covalently [...] Read more.
Plasminogen activators, such as recombinant tissue-type plasminogen activators (rtPAs), while effective in treating thromboembolic diseases, often induce hemorrhagic complications due to non-specific enzyme activities in the systemic circulation. This study evaluated the targeting efficiency, efficacy, biodistribution, and potential toxicity of a rtPA covalently attached to chitosan-coated magnetic nanoparticles (chitosan-MNP-rtPA). The thrombolytic activity of a chitosan-MNP-rtPA was preserved by protection from an endogenous plasminogen activator inhibitor-1 (PAI-1) in whole blood and after circulation in vivo, as examined by thromboelastometry. Single-photon emission computed tomography (SPECT) demonstrated real-time retention of a 99mTc-MNP-rtPA induced by magnet application in a rat embolic model; an 80% reduction in rtPA dosage for a chitosan-MNP-rtPA with magnetic guidance was shown to restore blood flow. After treatment, iron deposition was observed in the reticuloendothelial systems, with portal edema and neutrophil infiltration in the liver at a ten-fold higher dose but not the regular dose. Nevertheless, no liver or renal toxicity was observed at this higher dose. In conclusion, the liver may still be the major deposit site of rtPA nanocomposites after targeted delivery; chitosan-coated MNPs are potentially amenable to target therapeutics with parenteral administration. Full article
(This article belongs to the Special Issue Recent Advances in Biomedical Applications of Magnetic Nanomaterials)
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