Antiviral and Antibacterial: Focus on Novel Therapeutic Agents and Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 1006

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Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universitaà di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy
Interests: medicinal chemistry; drug discovery and development; antimycobacterial agents; antiviral agents; tuberculosis
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Special Issue Information

Dear Colleagues,

Innovative therapies against bacterial and viral diseases are an urgent need. The lack of a strong pipeline of anti-infective drugs and the increase of bacterial and viral resistance have caused a worldwide health crisis over the last decade, with well-known infectious diseases, such as AIDS and tuberculosis, still affecting millions of people worldwide. Moreover, three years of COVID-19 pandemic has taught us that also new and emerging pathogens can pose a serious threat to countries’ global health systems, demanding novel approaches in infectious disease drug development.

The aim of this Special Issue is to summarize recent research in the field of antiviral and antibacterial agents, covering all the stages and the aspects of novel candidates for infectious disease treatment, including biopharmaceuticals and innovative delivery protocols of both existing and novel antibacterials and antivirals. Potential topics to be covered include, but are not limited to:

  • Discovery and Development of novel and effective antibacterial and antiviral agents;
  • Innovative drug delivery systems for infectious diseases;
  • Repurposing drugs to treat these infections;
  • Innovative strategies to overcome drug resistance;
  • Host-targeted therapies.

Dr. Sara Consalvi
Guest Editor

Manuscript Submission Information

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Keywords

  • medicinal chemistry
  • antibacterials
  • antivirals
  • drug development
  • drug resistance
  • drug delivery
  • drug candidates
  • drug repurposing

Published Papers (1 paper)

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Research

25 pages, 1517 KiB  
Article
Effects of Combined Treatment with Sodium Dichloroacetate and Sodium Valproate on the Genes in Inflammation- and Immune-Related Pathways in T Lymphocytes from Patients with SARS-CoV-2 Infection with Pneumonia: Sex-Related Differences
by Donatas Stakišaitis, Linas Kapočius, Vacis Tatarūnas, Dovydas Gečys, Auksė Mickienė, Tomas Tamošuitis, Rasa Ugenskienė, Arūnas Vaitkevičius, Ingrida Balnytė and Vaiva Lesauskaitė
Pharmaceutics 2024, 16(3), 409; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics16030409 - 16 Mar 2024
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Abstract
The study presents data on the anti-inflammatory effects of a combination of sodium dichloroacetate and sodium valproate (DCA–VPA) on the expression of inflammation- and immune response-related genes in T lymphocytes of SARS-CoV-2 patients. The study aimed to assess the effects of DCA–VPA on [...] Read more.
The study presents data on the anti-inflammatory effects of a combination of sodium dichloroacetate and sodium valproate (DCA–VPA) on the expression of inflammation- and immune response-related genes in T lymphocytes of SARS-CoV-2 patients. The study aimed to assess the effects of DCA–VPA on the genes of cytokine activity, chemokine-mediated signaling, neutrophil chemotaxis, lymphocyte chemotaxis, T-cell chemotaxis, and regulation of T-cell proliferation pathways. The study included 21 patients with SARS-CoV-2 infection and pneumonia: 9 male patients with a mean age of 68.44 ± 15.32 years and 12 female patients with a mean age of 65.42 ± 15.74 years. They were hospitalized between December 2022 and March 2023. At the time of testing, over 90% of sequences analyzed in Lithuania were found to be of the omicron variant of SARS-CoV-2. The T lymphocytes from patients were treated with 5 mmol DCA and 2 mmol VPA for 24 h in vitro. The effect of the DCA–VPA treatment on gene expression in T lymphocytes was analyzed via gene sequencing. The study shows that DCA–VPA has significant anti-inflammatory effects and apparent sex-related differences. The effect is more potent in T cells from male patients with SARS-CoV-2 infection and pneumonia than in females. Full article
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