Nanodynamic Therapies against Cancer and Microbial Infections

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1312

Special Issue Editors


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Guest Editor
Department of Applied Chemistry, National Institute of Technology (KIT), Gumi, Gyeongbuk 39177, Republic of Korea
Interests: NIR-absorbing nanomaterials; cancer therapy; microbial infections; multimodel imaging
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Guest Editor
Department of Applied Chemistry, National Institute of Technology (KIT), Gumi, Gyeongbuk 39177, Republic of Korea
Interests: NIR-based nanoparticles; cancer therapy; phototherapy; chemodynamic therapy; multimodel imaging
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si, Gyeonggi-do 17104, Republic of Korea
Interests: biomaterials; hydrogels; drug delivery; polymers; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanodynamic therapies are emerging as one of the most highly effective therapeutic modalities for the treatment of cancers and microbial infections, particularly nanosensitizers that are capable of producing active free radicals/reactive oxygen species (ROS) upon stimuli to induce cell death. Nanodynamic therapies such as photodynamic therapy (PDT), chemodynamic therapy (CDT), sonodynamic therapy (SDT), thermodynamic therapy (TDT), radiodynamic therapy (RDT), electrodynamic therapy (EDT), piezoelectric dynamic therapy (PZDT), and pyroelectric dynamic therapy (PEDT) have been successfully introduced in recent years. In principle, the generation of ROS originates from two types of energy inputs such as exogenous energy activators (e.g., light, ultrasound (US), magnetic field, electricity, and ionizing irradiation) and endogenous chemical energy sources, including hydrogen peroxide (H2O2). Based on the high specificity of the external and internal triggers, these emerging dynamic therapies have achieved fast development and implementation very recently.

We invite all researchers to submit their findings related to nanomaterials for use in nanodynamic therapies against cancer and microbial infections.

This Special Issue, entitled “Nanodynamic Therapies against Cancer and Microbial Infections”, aims to collect many original research articles and reviews concerning the synthesis of various types of nanomaterials, their characterization,  in vitro and in vivo cancer and microbial infection studies, and clinical trials in pharmaceutical fields. In addition, research work that aims to increase our knowledge about the synthesis of various nanomaterials, their characterization, and the treatment of cancer and microbial infections are welcome.

We look forward to receiving your contributions.

Prof. Dr. Panchanathan Manivasagan
Prof. Dr. Eue-Soon Jang
Prof. Dr. Thambi Thavasyappan
Guest Editors

Manuscript Submission Information

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Keywords

  • various types of nanoparticles
  • sensitizer
  • ROS-activated cancer and microbial infection treatments
  • photodynamic therapy (PDT)
  • chemodynamic therapy (CDT)
  • sonodynamic therapy (SDT)
  • thermodynamic therapy (TDT)
  • radiodynamic therapy (RDT)
  • electrodynamic therapy (EDT)
  • piezoelectric dynamic therapy (PZDT)
  • pyroelectric dynamic therapy (PEDT)
  • other nanodynamic therapies
  • synthesis and characterization
  • in vitro and in vivo studies
  • synergistic nanodynamic therapy
  • cancer therapy
  • microbial infections
  • multimodal imaging
  • theranostics
  • tumor and bacterial targeting
  • ROS-responsive drug delivery system

Published Papers (1 paper)

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Research

21 pages, 10997 KiB  
Article
Mesoporous Silica-Layered Gold Nanorod Core@Silver Shell Nanostructures for Intracellular SERS Imaging and Phototherapy
by Sun-Hwa Seo, Ara Joe, Hyo-Won Han, Panchanathan Manivasagan and Eue-Soon Jang
Pharmaceutics 2024, 16(1), 137; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics16010137 - 19 Jan 2024
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Abstract
Precision diagnosis-guided efficient treatment is crucial to extending the lives of cancer patients. The integration of surface-enhanced Raman scattering (SERS) imaging and phototherapy into a single nanoplatform has been considered a more accurate diagnosis and treatment strategy for cancer nanotheranostics. Herein, we constructed [...] Read more.
Precision diagnosis-guided efficient treatment is crucial to extending the lives of cancer patients. The integration of surface-enhanced Raman scattering (SERS) imaging and phototherapy into a single nanoplatform has been considered a more accurate diagnosis and treatment strategy for cancer nanotheranostics. Herein, we constructed a new type of mesoporous silica-layered gold nanorod core@silver shell nanostructures loaded with methylene blue (GNR@Ag@mSiO2-MB) as a multifunctional nanotheranostic agent for intracellular SERS imaging and phototherapy. The synthesized GNR@Ag@mSiO2-MB nanostructures possessed a uniform core–shell structure, strong near-infrared (NIR) absorbance, photothermal conversion efficiency (65%), dye loading ability, SERS signal, and Raman stability under phototherapy conditions. Under single 785 nm NIR laser irradiation, the intracellular GNR@Ag@mSiO2-MB nanostructures were dramatically decreased to <9%, which showed excellent photothermal and photodynamic effects toward cancer cell killing, indicating that the combination of photothermal therapy (PTT) and photodynamic therapy (PDT) of the GNR@Ag@mSiO2-MB nanostructures could greatly enhance the therapeutic efficacy of cancer cell death. GNR@Ag@mSiO2-MB nanostructures demonstrated a strong Raman signal at 450 and 502 cm−1, corresponding to the δ(C–N–C) mode, suggesting that the Raman bands of GNR@Ag@mSiO2-MB nanostructures were more efficient to detect CT-26 cell SERS imaging with high specificity. Our results indicate that GNR@Ag@mSiO2-MB nanostructures offer an excellent multifunctional nanotheranostic platform for SERS imaging and synergistic anticancer phototherapy in the future. Full article
(This article belongs to the Special Issue Nanodynamic Therapies against Cancer and Microbial Infections)
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