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Pharmaceutics
Special Issues
Functional Biomaterials in Biomedical Applications
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Functional Biomaterials in Biomedical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 10 September 2024 | Viewed by 3938

Special Issue Editors

Dr. Anna Drabczyk

E-Mail Website
Guest Editor
CBRTP SA - Research and Development Center of Technology for Industry, Ludwika Waryńskiego 3A St., 00-645 Warsaw, Poland
Interests: innovative biomaterials; nanomaterials for biomedical applications; drug delivery systems; wound dressings
Special Issues, Collections and Topics in MDPI journals
Dr. Sonia Kudłacik-Kramarczyk

E-Mail Website
Guest Editor
Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, 8 Niezapominajek St., 30-239 Krakow, Poland
Interests: biomaterials; photopolymerization; emulsions; nanomaterials; polymer sorbents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In general, the term "biomaterial" refers to the material (natural or synthetic) which may be placed in the organism to replace the bodily function or the organ function as well as the material being a part of the implanted device. However, along with the progress of medicine, chemical technology and material engineering, many studies are being performed to design biomaterial which can, e.g., also stimulate tissue regeneration, deliver the therapeutic agent or protect against bacterial infection. Thus, on one hand, a growing number of requirements are placed on biomaterials, and on the other hand, the currently developed biomaterials are increasingly more advanced in their functionality. Therefore, the main aim of this Special Issue is to present current research works focusing on designing functional biomaterials for biomedical applications, including, for example, controlled drug delivery systems, composite biomaterials, scaffolds for tissue regeneration, bioactive coatings, and implants. Papers focusing on the interactions or processes occurring within the biomaterial–organism system will also be welcome.

Dr. Anna Drabczyk
Dr. Sonia Kudłacik-Kramarczyk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems 
  • scaffolds 
  • bioactive coatings 
  • implants 
  • biomaterial-organism interactions

Published Papers (3 papers)

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Research

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16 pages, 6430 KiB  
Article
Linseed Oil-Based Oleogel Vehicles for Hydrophobic Drug Delivery—Physicochemical and Applicative Properties
by Sonia Kudłacik-Kramarczyk, Anna Drabczyk, Alicja Przybyłowicz and Marcel Krzan
Pharmaceutics 2024, 16(5), 600; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics16050600 (registering DOI) - 29 Apr 2024
Viewed by 164
Abstract
In this study, a methodology for synthesizing oleogels based on linseed oil and emulsifiers, such as beeswax and Tween 20 and Tween 80, was developed. Linseed oil served as the main oil phase, while beeswax acted as a gelling and emulsifying agent. Tween [...] Read more.
In this study, a methodology for synthesizing oleogels based on linseed oil and emulsifiers, such as beeswax and Tween 20 and Tween 80, was developed. Linseed oil served as the main oil phase, while beeswax acted as a gelling and emulsifying agent. Tween compounds are non-ionic surfactants composed of hydrophobic and hydrophilic parts, allowing for the formation of a stable system with promising properties. Surface wetting analysis of the obtained oleogels, FT-IR spectroscopy, and determination of relative and absolute humidity over time, as well as optical microscope analysis and rheological analysis of the obtained oleogels, were conducted as part of the research. The results indicate that increasing the amount of Tween 20 decreases the hydrophilicity of the oleogel, while Tween 80 exhibits the opposite effect. Surface energy analysis suggests that a higher content of Tween 20 may lead to a reduction in the surface energy of the oleogels, which may indicate greater material stability. Changes in relative humidity and FT-IR spectral analysis confirm the influence of emulsifiers on the presence of characteristic functional groups in the structure of the oleogels. Additionally, microscopic analysis suggests that an emulsifier with a longer hydrophobic tail leads to a denser material structure. Full article
(This article belongs to the Special Issue Functional Biomaterials in Biomedical Applications)
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24 pages, 9337 KiB  
Article
Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of N-Vinylpyrrolidone
by Yuliya V. Soldatova, Irina I. Faingold, Darya A. Poletaeva, Alexei V. Kozlov, Nina S. Emel’yanova, Igor I. Khodos, Dmitry A. Chernyaev and Svetlana V. Kurmaz
Pharmaceutics 2023, 15(5), 1388; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics15051388 - 30 Apr 2023
Cited by 2 | Viewed by 1154
Abstract
Water-soluble forms of α-tocopherol (TP) as an effective antioxidant were obtained by encapsulating it into nanoparticles (NPs) of amphiphilic copolymers of N-vinylpyrrolidone with triethylene glycol dimethacrylate (CPL1-TP) and N-vinylpyrrolidone with hexyl methacrylate and triethylene glycol dimethacrylate (CPL2-TP) synthesized by radical copolymerization [...] Read more.
Water-soluble forms of α-tocopherol (TP) as an effective antioxidant were obtained by encapsulating it into nanoparticles (NPs) of amphiphilic copolymers of N-vinylpyrrolidone with triethylene glycol dimethacrylate (CPL1-TP) and N-vinylpyrrolidone with hexyl methacrylate and triethylene glycol dimethacrylate (CPL2-TP) synthesized by radical copolymerization in toluene. The hydrodynamic radii of NPs loaded with TP (3.7 wt% per copolymers) were typically ca. 50 or 80 nm depending on copolymer composition, media, and temperature. Characterization of NPs was accomplished by transmission electron microscopy (TEM), IR-, and 1H NMR spectroscopy. Quantum chemical modeling showed that TP molecules are capable to form hydrogen bonds with donor groups of the copolymer units. High antioxidant activity of both obtained forms of TP has been found by the thiobarbituric acid reactive species and chemiluminescence assays. CPL1-TP and CPL2-TP effectively inhibited the process of spontaneous lipid peroxidation as well as α-tocopherol itself. The IC50 values of luminol chemiluminescence inhibition were determined. Antiglycation activity against vesperlysine and pentosidine-like AGEs of TP water-soluble forms was shown. The developed NPs of TP are promising as materials with antioxidant and antiglycation activity and can be used in various biomedical applications. Full article
(This article belongs to the Special Issue Functional Biomaterials in Biomedical Applications)
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Review

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24 pages, 1972 KiB  
Review
Advances in Polysaccharide- and Synthetic Polymer-Based Vitreous Substitutes
by Kruti Naik, Lisa C. Du Toit, Naseer Ally and Yahya E. Choonara
Pharmaceutics 2023, 15(2), 566; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics15020566 - 08 Feb 2023
Cited by 1 | Viewed by 2177
Abstract
The vitreous humour is a gel-like structure that composes the majority of each eye. It functions to provide passage of light, be a viscoelastic dampener, and hold the retina in place. Vitreous liquefaction causes retinal detachment and retinal tears requiring pars plana vitrectomy [...] Read more.
The vitreous humour is a gel-like structure that composes the majority of each eye. It functions to provide passage of light, be a viscoelastic dampener, and hold the retina in place. Vitreous liquefaction causes retinal detachment and retinal tears requiring pars plana vitrectomy for vitreous substitution. An ideal vitreous substitute should display similar mechanical, chemical, and rheological properties to the natural vitreous. Currently used vitreous substitutes such as silicone oil, perfluorocarbon liquids, and gases cannot be used long-term due to adverse effects such as poor retention time, cytotoxicity, and cataract formation. Long-term, experimental vitreous substitutes composed of natural, modified and synthetic polymers are currently being studied. This review discusses current long- and short-term vitreous substitutes and the disadvantages of these that have highlighted the need for an ideal vitreous substitute. The review subsequently focuses specifically on currently used polysaccharide- and synthetic polymer-based vitreous substitutes, which may be modified or functionalised, or employed as the derivative, and discusses experimental vitreous substitutes in these classes. The advantages and challenges associated with the use of polymeric substitutes are discussed. Innovative approaches to vitreous substitution, namely a novel foldable capsular vitreous body, are presented, as well as future perspectives related to the advancement of this field. Full article
(This article belongs to the Special Issue Functional Biomaterials in Biomedical Applications)
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