Design of Novel Nanoparticles for Enhanced Antibacterial Activity

Dear Colleagues,

The aim of this Special Issue is to explore innovative approaches to combat bacterial infections through the development of advanced nanoparticle-based systems. Nanoparticles used for drug delivery include numerous structures capable of transporting active ingredients through different administration routes, offering advantages such as drug protection, an easier access of the drug across biological membranes, prolonged drug release, and the possibility of reducing the dosing frequency. In recent years, the rise of antibiotic resistance has underscored the urgent need for novel therapeutic strategies. Antimicrobial drugs act on the specific structures or targets of microbial cells; however, resistance mechanisms can cause microorganisms to spread without responding to treatment. The role of nanoparticles as antimicrobial drug delivery systems is crucial, since these nanocarriers can protect drugs from degradation and facilitate their passage through the cell membrane of microorganisms. Consequently, nanoparticles could improve drug efficacy, minimize toxicity, and circumvent microbial resistance mechanisms. We invite researchers from various disciplines to submit high-quality, original manuscripts on the design, synthesis, and application of nanoparticles with enhanced antibacterial properties. Contributions may include studies on the optimization of different types of nanocarriers including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), polymeric nanoparticles, nanocrystals, nanoemulsions, microemulsions, and vesicular nanocarriers, with all geared towards maximizing the antibacterial efficacy while minimizing adverse effects.

Dr. Mireia Mallandrich Miret
Dr. Lupe Carolina Espinoza
Guest Editors

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• antibacterial activity
• antibiotic
• antimicrobial
• nanoparticles
• nanocarriers