Self-Assembled Amphiphilic Copolymers in Drug Delivery, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 1024

Special Issue Editors

Department of Exact Sciences, “Ion Ionescu de la Brad” Iasi University of Life Sciences, 700490 Iasi, Romania
Interests: self-assembled materials; drug delivery systems; controlled release; biomaterials; polymers; liposomes; nanoparticles nanocomposites; nanomaterials synthesis and characterization;
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Guest Editor
Centre of Advanced Research in Bionanoconjugates and Biopolymers, Petru Poni Institute of Macromolecular Chemistry, 700487 Iasi, Romania
Interests: hybrid nanomaterials; G-quartet hydrogels; nanomaterials synthesis and characterization; Atomic Force Microscopy; Raman and SERS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to publish your valuable research results in this Special Issue titled “Self-Assembled Amphiphilic Copolymers in Drug Delivery, 2nd Edition”. Amphiphilic copolymers present a unique chemical structure that includes both hydrophilic and hydrophobic chains, which trigger a self-assembling behavior in selective solvents due to the hydrophilic/hydrophobic interactions among different polymer blocks. Based on this behavior, amphiphilic copolymers can form micelles or polymer vesicles (polymersomes), making them attractive for numerous applications in biomedicine, including their usage as drug delivery systems. There is a high demand for new drug-polymer formulations to be used as effective carriers that allow for an efficient controlled release of the active substance in the targeted area. From this point of view, amphiphilic copolymers are emerging in biomedicine, where there is a stringent need for a system responsive to external stimuli (pH, temperature, solvents, etc.) and that is capable of loading and releasing the incorporated drug.

This Special Issue aims to collect papers related to all aspects regarding the development (process engineering, synthesis, characterization, theoretical modelling, etc.) of self-assembled amphiphilic copolymers and their application as new drug delivery systems. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Synthesis routes and property control;
  • Fine tuning of amphiphilic copolymers’ properties;
  • Chemical modifications of amphiphilic copolymers;
  • Process engineering of polymer matrices;
  • Encapsulation and delivery of hydrophilic drugs from hydrophobic copolymers;
  • Encapsulation and delivery of hydrophobic drugs from hydrophilic copolymers;
  • Controlled drug delivery studies;
  • Drug targeting.

We look forward to receiving your contributions.

Dr. Ana Cazacu
Dr. Elena-Laura Ursu
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • self-assembly
  • amphiphilic block copolymers
  • nanostructures
  • drug delivery systems
  • targeted drug delivery
  • controlled release
  • kinetics studies
  • carriers
  • micelles
  • polymersomes

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Published Papers (1 paper)

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Review

30 pages, 2633 KiB  
Review
Polymersomes as Innovative, Stimuli-Responsive Platforms for Cancer Therapy
by Irina Negut and Bogdan Bita
Pharmaceutics 2024, 16(4), 463; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics16040463 - 26 Mar 2024
Viewed by 665
Abstract
This review addresses the urgent need for more targeted and less toxic cancer treatments by exploring the potential of multi-responsive polymersomes. These advanced nanocarriers are engineered to deliver drugs precisely to tumor sites by responding to specific stimuli such as pH, temperature, light, [...] Read more.
This review addresses the urgent need for more targeted and less toxic cancer treatments by exploring the potential of multi-responsive polymersomes. These advanced nanocarriers are engineered to deliver drugs precisely to tumor sites by responding to specific stimuli such as pH, temperature, light, hypoxia, and redox conditions, thereby minimizing the side effects associated with traditional chemotherapy. We discuss the design, synthesis, and recent applications of polymersomes, emphasizing their ability to improve therapeutic outcomes through controlled drug release and targeted delivery. Moreover, we highlight the critical areas for future research, including the optimization of polymersome–biological interactions and biocompatibility, to facilitate their clinical adoption. Multi-responsive polymersomes emerge as a promising development in nanomedicine, offering a pathway to safer and more effective cancer treatments. Full article
(This article belongs to the Special Issue Self-Assembled Amphiphilic Copolymers in Drug Delivery, 2nd Edition)
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