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Pharmaceutics
Special Issues
Recent Advances in Nanotechnology Therapeutics
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Recent Advances in Nanotechnology Therapeutics

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 847

Special Issue Editor

Dr. Hyun-ouk Kim

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Guest Editor
Department of Biotechnology and Bioengineering, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea
Interests: cancer; infectious diseases; nanoencapsulation; nanomedicine; nanoparticles; new drug delivery systems; polymersome; theragnosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our upcoming Special Issue on "Recent Advances in Nanotechnology Therapeutics" in Pharmaceutics. This Special Issue aims at unveiling the latest developments and breakthroughs in nanotechnology applications for therapeutic purposes. Nanotechnology has shown immense potential in offering targeted solutions for drug delivery, diagnostics, and monitoring treatments. We seek to compile a collection of high-quality research papers and review articles that delve into the multifaceted advances in nanotechnology therapeutics.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Novel nanocarrier systems for targeted drug delivery;
  • Nanoparticle-based imaging techniques for early cancer detection and diagnosis;
  • Theranostic nanomedicine platforms for simultaneous imaging and therapy;
  • Overcoming biological barriers using nanotechnology for improved drug delivery; 
  • Nanoparticle formulations for combination therapy; 
  • Biocompatibility and safety assessment of nanomaterials for clinical translation;
  • Nanotechnology-based approaches for personalized cancer medicine.

We look forward to receiving your contributions.

Dr. Hyun-ouk Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotechnology
  • cancer treatment
  • drug delivery systems
  • diagnostic imaging
  • personalized medicine

Published Papers (1 paper)

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Research

21 pages, 3557 KiB  
Article
Effect of Micromixer Design on Lipid Nanocarriers Manufacturing for the Delivery of Proteins and Nucleic Acids
by Enrica Chiesa, Alessandro Caimi, Marco Bellotti, Alessia Giglio, Bice Conti, Rossella Dorati, Ferdinando Auricchio and Ida Genta
Pharmaceutics 2024, 16(4), 507; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics16040507 - 07 Apr 2024
Viewed by 446
Abstract
Lipid-based nanocarriers have emerged as helpful tools to deliver sensible biomolecules such as proteins and oligonucleotides. To have a fast and robust microfluidic-based nanoparticle synthesis method, the setup of versatile equipment should allow for the rapid transfer to scale cost-effectively while ensuring tunable, [...] Read more.
Lipid-based nanocarriers have emerged as helpful tools to deliver sensible biomolecules such as proteins and oligonucleotides. To have a fast and robust microfluidic-based nanoparticle synthesis method, the setup of versatile equipment should allow for the rapid transfer to scale cost-effectively while ensuring tunable, precise and reproducible nanoparticle attributes. The present work aims to assess the effect of different micromixer geometries on the manufacturing of lipid nanocarriers taking into account the influence on the mixing efficiency by changing the fluid–fluid interface and indeed the mass transfer. Since the geometry of the adopted micromixer varies from those already published, a Design of Experiment (DoE) was necessary to identify the operating (total flow, flow rate ratio) and formulation (lipid concentration, lipid molar ratios) parameters affecting the nanocarrier quality. The suitable application of the platform was investigated by producing neutral, stealth and cationic liposomes, using DaunoXome®, Myocet®, Onivyde® and Onpattro® as the benchmark. The effect of condensing lipid (DOTAP, 3–10–20 mol%), coating lipids (DSPE-PEG550 and DSPE-PEG2000), as well as structural lipids (DSPC, eggPC) was pointed out. A very satisfactory encapsulation efficiency, always higher than 70%, was successfully obtained for model biomolecules (myoglobin, short and long nucleic acids). Full article
(This article belongs to the Special Issue Recent Advances in Nanotechnology Therapeutics)
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